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Immunology and Infection

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JoVE Journal Immunology and Infection
A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
 

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Article DOI: 10.3791/56443-v • 07:38 min • April 13th, 2018
April 13th, 2018 •
1, 2, 2, 3, 3, 4, 1, 2, 5, 1
1Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science, University of Parma, 3Department of Molecular Genetics, Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology, Erasmus MC, 5Fluidda NV

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Summary
Automatic Translation

We describe a non-invasive multimodal imaging approach based on Micro-CT and fluorescence molecular tomography for longitudinal assessment of the mouse lung fibrosis model induced by double intratracheal instillation of bleomycin.

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Keywords: Micro-CT Fluorescence Molecular Tomography Lung Fibrosis IPF Mouse Model Longitudinal Assessment Non-invasive Imaging Bleomycin Probe Injection Data Acquisition Imaging Cassette
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