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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
 

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Article DOI: 10.3791/56476-v • 05:12 min • September 4th, 2017
September 4th, 2017 •
1,2, 3, 4, 1, 1,2,3
1Lab of Cardiovascular Signaling, Centenary Institute, 2Faculty of Medicine, Sydney Medical School, University of Sydney, 3Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, 4Australian Centre for Microscopy & Microanalysis, University of Sydney

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Summary
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This protocol demonstrates the induction of cerebral cavernous malformation disease in a mouse model and uses contrast enhanced micro computed tomography to measure lesion burden. This method enhances the value of established mouse models to study the molecular basis and potential therapies for cerebral cavernous malformation and other cerebrovascular diseases.

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Keywords: Cerebral Cavernous Malformations Neonatal Mice Micro-CT Imaging 4-HT Paraformaldehyde Lugol's Iodine Tissue Preparation Brain Imaging Vascular Disease
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