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Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
 

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Article DOI: 10.3791/57452-v • 09:18 min • July 16th, 2018
July 16th, 2018 •
1, 1, 1, 1,2
1Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

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Summary
Automatic Translation

Tumor-seeking therapeutic mesenchymal stem cells (MSCs) show promise as a treatment for invasive glioblastoma. Optimal transplantation involves delivery of MSCs into the tumor resection cavity on scaffolds. Here, preclinical techniques to study MSC treatment of glioblastoma are provided including: image-guided tumor resection; implantation of MSC-seeded scaffolds; and postoperative therapy tracking.

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Keywords: Image-guided Resection Glioblastoma Intracranial Implantation Therapeutic Stem Cell Scaffold Cell Therapy Neuro-oncology Surgical Resection Scaffold-based Delivery PLA Scaffold Mesenchymal Stem Cells (MSCs) Cell Seeding
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