Journal
/
Bioengineering
/
Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex
JoVE Journal
Bioengineering
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Bioengineering
Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

DOI:
10.3791/57829-v

•

10:42 min

•

August 18, 2018

•

, , , , , ,
1Advanced Platform Technology Center, Rehabilitation Research and Development,Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering,Case Western Reserve University

Chapters

  • 00:04Title
  • 00:31Microelectrode Implantation Surgical Procedure
  • 03:16Insertion of Microelectrode in Motor Cortex
  • 04:57Behavioral Testing
  • 08:16Results: Representative Ladder Test and Grip Strength Test Results
  • 09:57Conclusion

Summary

Automatic Translation

Automatic Translation

We have shown that a microelectrode implantation in the motor cortex of rats causes immediate and lasting motor deficits. The methods proposed herein outline a microelectrode implantation surgery and three rodent behavioral tasks to elucidate potential changes in the fine or gross motor function due to implantation-caused damage to the motor cortex.

Tags

Keywords: RodentBehavioral TestingFunctional DeficitsMicroelectrode ImplantationRat Motor CortexNeural EngineeringMotor FunctionSurgical ProcedureStereotaxic FrameCephalosporin AntibioticBupivacaineBetadineCyanoacrylateDental CementDuraMotor CortexForepaw Movement

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/57829?article_type=v

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context
check_url/57829?article_type=v

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
check_url/57829?article_type=v

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
check_url/57829?article_type=v

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
check_url/57829?article_type=v

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
check_url/57829?article_type=v

Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate (LAL) Assays
check_url/57829?article_type=v

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
check_url/57829?article_type=v

The Quantification of Injectability by Mechanical Testing
check_url/57829?article_type=v

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How “Molecular Surgery” of the Backbone Affects Folding and Stability
check_url/57829?article_type=v

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Read Article