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大鼠运动皮质微电极植入所致功能缺损的啮齿动物行为检测

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

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大鼠运动皮质微电极植入所致功能缺损的啮齿动物行为检测

DOI:

10.3791/57829-v

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10:42 min

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August 18, 2018

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Monika Goss-Varley², Andrew J. Shoffstall², Keith R. Dona², Justin A. McMahon², Sydney C. Lindner², Evon S. Ereifej², Jeffrey R. Capadona²

¹Advanced Platform Technology Center, Rehabilitation Research and Development,Louis Stokes Cleveland Department of Veterans Affairs Medical Center, ²Department of Biomedical Engineering,Case Western Reserve University

Chapters

00:04Title
00:31Microelectrode Implantation Surgical Procedure
03:16Insertion of Microelectrode in Motor Cortex
04:57Behavioral Testing
08:16Results: Representative Ladder Test and Grip Strength Test Results
09:57Conclusion

Summary

Automatic Translation

我们已经表明, 在大鼠的运动皮层的微电极植入导致立即和持久的运动缺陷。本文提出的方法概述了微电极植入手术和三啮齿目动物行为任务, 以阐明由于植入造成的运动皮层损伤的细微或总运动功能的潜在变化。

Tags

Keywords: Rodent Behavioral Testing Functional Deficits Microelectrode Implantation Rat Motor Cortex Neural Engineering Motor Function Surgical Procedure Stereotaxic Frame Cephalosporin Antibiotic Bupivacaine Betadine Cyanoacrylate Dental Cement Dura Motor Cortex Forepaw Movement

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