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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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1Wallace H. Coulter Department of Biomedical Engineering,Georgia Tech College of Engineering and Emory School of Medicine, 2Parker H. Petit Institute of Bioengineering and Bioscience, 3Institute for Electronics and Nanotechnology,Georgia Tech, 4Integrated Cancer Research Center,Georgia Tech, 5The Georgia Immunoengineering Consortium,Emory University and Georgia Tech
Chapters
- 00:04Title
- 00:36Iron Oxide Nanoparticle (IONP) Synthesis
- 05:22Peptide Design, Conjugation to Iron Oxide Nanoparticles, and In Vitro Validation
- 07:10Administration of Nanosensors and Urine Detection of Cancer
- 08:18Results: Detecting Protease Activity
- 09:52Conclusion
Proteases are tightly regulated enzymes involved in fundamental biological processes, and dysregulated protease activity drives progression of complex diseases such as cancer. This method's goal is to create nanosensors that measure protease activity in vivo by producing a cleavage signal that is detectable from host urine and discriminates disease.
