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Bioengineering
/
纳米传感器检测
体内
蛋白酶活性的无创诊断
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
Nanosensors to Detect Protease Activity
In Vivo
for Noninvasive Diagnostics
Please note that all translations are automatically generated.
Click here for the English version.
纳米传感器检测
体内
蛋白酶活性的无创诊断
DOI:
10.3791/57937-v
•
10:50 min
•
July 16, 2018
•
Brandon Alexander Holt
,
Quoc D. Mac
,
Gabriel A. Kwong
2,3,4,5
1
Wallace H. Coulter Department of Biomedical Engineering
,
Georgia Tech College of Engineering and Emory School of Medicine
,
2
Parker H. Petit Institute of Bioengineering and Bioscience
,
3
Institute for Electronics and Nanotechnology
,
Georgia Tech
,
4
Integrated Cancer Research Center
,
Georgia Tech
,
5
The Georgia Immunoengineering Consortium
,
Emory University and Georgia Tech
Chapters
00:04
Title
00:36
Iron Oxide Nanoparticle (IONP) Synthesis
05:22
Peptide Design, Conjugation to Iron Oxide Nanoparticles, and In Vitro Validation
07:10
Administration of Nanosensors and Urine Detection of Cancer
08:18
Results: Detecting Protease Activity
09:52
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
蛋白酶是严格调控的酶参与基本的生物学过程, 失调蛋白酶活动推动复杂疾病, 如癌症的进展。该方法的目的是创造纳米传感器, 以测量
体内
蛋白酶的活动, 产生一个可从宿主尿和歧视性疾病检测到的裂解信号。
Tags
Nanosensors
Protease Activity
In Vivo
Noninvasive Diagnostics
Protease Detection
Disease Progression
Pathogenesis
Chemical Synthesis
Ammonium Hydroxide
Dextrin
Iron Chloride
Deoxygenation
Nucleation
Nanoparticle Synthesis
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