Journal
/
/
纳米传感器检测体内蛋白酶活性的无创诊断
JoVE Journal
Bioengineering
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Bioengineering
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
DOI:

10:50 min

July 16, 2018

, ,

Chapters

  • 00:04Title
  • 00:36Iron Oxide Nanoparticle (IONP) Synthesis
  • 05:22Peptide Design, Conjugation to Iron Oxide Nanoparticles, and In Vitro Validation
  • 07:10Administration of Nanosensors and Urine Detection of Cancer
  • 08:18Results: Detecting Protease Activity
  • 09:52Conclusion

Summary

Automatic Translation

蛋白酶是严格调控的酶参与基本的生物学过程, 失调蛋白酶活动推动复杂疾病, 如癌症的进展。该方法的目的是创造纳米传感器, 以测量体内蛋白酶的活动, 产生一个可从宿主尿和歧视性疾病检测到的裂解信号。

Related Videos

Read Article