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Medicine
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慢性血栓栓塞性肺动脉高压大型动物模型中急性右心衰竭的诱导和表型分析
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JoVE Journal
Medicine
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Please note that all translations are automatically generated.
Click here for the English version.
慢性血栓栓塞性肺动脉高压大型动物模型中急性右心衰竭的诱导和表型分析
DOI:
10.3791/58057-v
•
07:41 min
•
March 17, 2022
•
David Boulate
,
Myriam Amsallem
2
,
Jean-Baptiste Menager
,
Simon Dang Van
,
Peter Dorfmuller
,
Andrew Connolly
,
Alban Todesco
,
Benoit Decante
,
Elie Fadel
,
Francois Haddad
,
Olaf Mercier
1
Research and Innovation Unit, RHU BioArt Lung 2020
,
Marie Lannelongue Hospital
,
2
Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute
,
Stanford University
,
3
Department of pathology
,
Marie Lannelongue Hospital
,
4
Department of pathology
,
UCSF School of Medicine
,
5
Department of thoracic surgery, Hopital Nord, APHM
,
Aix-Marseille University
Chapters
00:04
Introduction
00:39
Catheter Placement
01:44
Echocardiography
02:19
Right Heart Catheterization and Pressure Volume Loop Acquisition
03:20
Acute Right Heart Failure Induction
03:58
Pressure Overload with Iterative Pulmonary Embolism Induction
04:40
Systemic Hemodynamic Restoration
05:30
Results: Representative Acute Right Heart Failure Phenotype Analyses
07:07
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们提出了一种方案,用于在慢性肺动脉高压的大型动物模型中诱导和表型急性右心衰竭。该模型可用于测试治疗干预,开发右心指标或提高对急性右心衰竭病理生理学的理解。
Tags
Acute Right Heart Failure
Chronic Thromboembolic Pulmonary Hypertension
Large Animal Model
Induction
Phenotyping
Volume Overload
Pressure Overload
Seldinger Method
Jugular Vein
Femoral Artery
Femoral Vein
Balloon Dilation Catheter
Echocardiography
Right Heart Catheterization
Swan-Ganz Catheter
Thermodilution
Pressure-volume Loop
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