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慢性血栓栓塞性肺动脉高压大型动物模型中急性右心衰竭的诱导和表型分析
JoVE Journal
Medicine
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JoVE Journal Medicine
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
DOI:

07:41 min

March 17, 2022

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Chapters

  • 00:04Introduction
  • 00:39Catheter Placement
  • 01:44Echocardiography
  • 02:19Right Heart Catheterization and Pressure Volume Loop Acquisition
  • 03:20Acute Right Heart Failure Induction
  • 03:58Pressure Overload with Iterative Pulmonary Embolism Induction
  • 04:40Systemic Hemodynamic Restoration
  • 05:30Results: Representative Acute Right Heart Failure Phenotype Analyses
  • 07:07Conclusion

Summary

Automatic Translation

我们提出了一种方案,用于在慢性肺动脉高压的大型动物模型中诱导和表型急性右心衰竭。该模型可用于测试治疗干预,开发右心指标或提高对急性右心衰竭病理生理学的理解。

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