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高效液相色谱法测定犬尿氨和 Kynurenic 酸: 对大鼠认知和睡眠的相关生物化学研究
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JoVE Journal Behavior
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
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高效液相色谱法测定犬尿氨和 Kynurenic 酸: 对大鼠认知和睡眠的相关生物化学研究

DOI:
10.3791/58129-v

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07:04 min

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August 19, 2018

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, , ,
1Maryland Psychiatric Research Center, Department of Psychiatry,University of Maryland School of Medicine, 2Department of Pharmacology,University of Maryland School of Medicine

Chapters

  • 00:04Title
  • 00:40Sample Preparation
  • 02:10High-performance Liquid Chromatography (HPLC) Kynurenine Measurement
  • 05:17Results: Effects of Kynurenine Elevation on Hippocampal-dependent Memory and Sleep-wake Architecture
  • 06:44Conclusion

Summary

Automatic Translation

Automatic Translation

犬尿氨通路 (KP) neuroactive 代谢物的改变与精神疾病有牵连。调查啮齿类动物体内改变的犬尿氨通路代谢的功能性结果可能有助于阐明新的治疗方法。目前的协议结合了生物化学和行为学的方法来研究急性犬尿氨挑战对大鼠的影响。

Tags

High-performance Liquid ChromatographyKynurenineKynurenic AcidNeuroscienceRatsBiochemistryCognitionSleep

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