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Potentiering av Anticancer antikropp effekt av antineoplastiska läkemedel: Påvisande av antikropp-drogen Synergism med kombination Index formel
JoVE Journal
Cancer Research
Author Produced
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JoVE Journal Cancer Research
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
DOI:

15:04 min

January 19, 2019

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Chapters

  • 00:00Title
  • 01:38Evaluation of the Drug Interaction between mAb 8B6 and Topotecan in vitro
  • 07:35Generation of Human IMR5 Neuroblastoma Xenografts in NSG Mice
  • 12:18Representative Results
  • 14:09Conclusion

Summary

Automatic Translation

Det här protokollet beskriver hur man skall bedöma synergier mellan en anticancer antikropp och antineoplastiska läkemedel i prekliniska modeller med hjälp av kombination index ekvation av Chou och Talalay.

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