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palt1 副酶活性对髓系先天信号通路的调控
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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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palt1 副酶活性对髓系先天信号通路的调控

DOI:
10.3791/58439-v

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07:09 min

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January 07, 2019

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, , , , , ,
1Autoimmunity, Transplantation and Inflammation,Novartis Institutes for BioMedical Research

Chapters

  • 00:04Title
  • 00:51Preparation of Peripheral Blood Mononuclear Cells (PBMCs) from Human Buffy Coats
  • 02:48PBMCs Treatments and Stimulatory Conditions
  • 03:45Compound Preparation
  • 04:20Stimuli Preparation
  • 04:42Results: Signaling Pathway Regulation by MALT1 Paracaspase Activity
  • 06:40Conclusion

Summary

Automatic Translation

Automatic Translation

alt1 调节先天免疫, 但这种情况是如何发生的仍未确定。我们使用选择性 malt1 副囊酶抑制剂 mlt-827 来解开 malt1 对 toll 样或 c 型凝集素受体下游的先天信号的贡献, 证明 malt1 调节骨髓细胞因子的产生, 并在下游c 型乳素样受体, 选择性的。

Tags

Keywords: Myeloid CellsSignaling PathwaysPattern Recognition ReceptorsPrimary Cell PreparationsDensity Gradient CentrifugationRed Blood Cell LysisCellular StimulationCell CultureCompound Screening

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