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JoVE Journal Bioengineering
Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
 

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Article DOI: 10.3791/58487-v • 08:42 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1
1Department of Biomedical Engineering, University of Rochester

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Summary
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We present a method to assess the spatial extent of cell injury/death on the articular surface of intact murine joints after application of controlled mechanical loads or impacts. This method can be used to investigate how osteoarthritis, genetic factors and/or different loading regimens affect the vulnerability of in situ chondrocytes.

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Keywords: Real-time Visualization Chondrocyte Injury Mechanical Loading Murine Cartilage Explants Articular Chondrocytes Mouse Model Femur Dissection Knee Joint Cartilage Degeneration Mechanical Injury
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