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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
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Medicine
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JoVE Journal Medicine
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

DOI:
10.3791/59631-v

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08:04 min

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January 24, 2020

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, ,
1Department of Ophthalmology,Stony Brook University, 2Department of Preventive Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc.

Chapters

  • 00:04Title
  • 01:25Nictitating Membrane Injection and Removal
  • 02:41Dry Eye Induction
  • 06:15Results: Representative Effects of Aqueous-Deficient Dry Eye Disease (DED) Induction
  • 07:19Conclusion

Summary

Automatic Translation

Automatic Translation

This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents.

Tags

Rabbit ModelAqueous-deficient Dry Eye DiseaseConcanavalin ALacrimal Gland InjectionUltrasound GuidanceAnimal ModelDrug Efficacy StudiesPathophysiology

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