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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

JoVE Journal
Chemistry

This content is Free Access.

JoVE Journal Chemistry

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

DOI:

10.3791/60021-v

•

09:44 min

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October 15, 2019

•

Akinobu Z. Suzuki, Yukiko Shiraishi, Hanami Aoki, Hirona Sasaki, Rei Watahiki, Toshiaki Furuta

¹Department of Biomolecular Science, Faculty of Science,Toho University

Chapters

00:04Title
00:57Clickable Caged Amine Preparation
01:53Functional Unit Installation
03:12Quantum Efficiency Measurements at 350 nm
03:59HaloTag Ligand Targeting
06:28Photomediated Kinase Localization Modulation
07:33Results: Physical, Photochemical, and Functional Properties of Clickable Caged Compounds
09:05Conclusion

Summary

Automatic Translation

A protocol for the synthesis and measurement of the photochemical properties of modular caged compounds with clickable moieties is presented.

Tags

Keywords: Clickable Caged Compounds Photocaged Compounds Water Solubility Cellular Targeting Photosensitivity PaBhc N-carbonyldiimidazole 4-Dimethylaminopyridine Tert-butyl 6-amino Hexyl Carbamate Copper Sulfate Tris(3-hydroxypropyltriazolylmethyl)amine Sodium-l-ascorbate 15-chloro-3 6 9-trioxypentyldecyl Azide HPLC Quantum Efficiency

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