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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
 

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Article DOI: 10.3791/58631-v • 10:10 min • January 17th, 2019
January 17th, 2019 •
1, 1, 1, 1,2
1Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 2Riken Center for Emergent Matter Science

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Summary
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This protocol describes light-triggered nuclear translocation of guests in living cells using caged molecular glue tags. This method is promising for site-selective nuclear-targeting drug delivery.

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Keywords: Nuclear Translocation Caged Molecular Glue Photoactivatable Tags Quantum Dot Drug Delivery HEP3B Cells Fluorescent Dye Endosomes
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