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Immunology and Infection

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JoVE Journal Immunology and Infection
Chronic Salmonella Infection Induced Intestinal Fibrosis
 

Chronic Salmonella Infection Induced Intestinal Fibrosis

Article DOI: 10.3791/60068-v • 08:40 min • September 22nd, 2019
September 22nd, 2019 •
1, 1, 1, 1
1The Biomedical Research Centre, University of British Columbia

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Summary
Automatic Translation

This protocol describes a mouse model of Salmonella driven intestinal fibrosis that resembles key pathological hallmarks of Crohn’s disease including transmural inflammation and fibrosis. This method can be used to evaluate host factors that alter fibrotic outcomes using mutant mice maintained on a C57Bl/6 genetic background.

Tags

Keywords: Intestinal Fibrosis Chronic Inflammation Crohn's Disease Salmonella Infection Mouse Model Oral Gavage Streptomycin LB Agar LB Broth Bacterial Culture Sterile Technique
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