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Immunology and Infection
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Kronisk, akut, og reaktiveret HIV-infektion i humaniserede immundefekt musemodeller
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Immunology and Infection
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JoVE Journal Immunology and Infection
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Kronisk, akut, og reaktiveret HIV-infektion i humaniserede immundefekt musemodeller

DOI:
10.3791/60315-v

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09:54 min

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December 03, 2019

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, , , , ,
1Institute of Human Virology, School of Medicine,University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina,Universidad de Antioquia

Chapters

  • 00:04Title
  • 00:45Human CD34+ Hematopoietic Stem Cells (HSC) Engraftment of Newborn Mice
  • 04:18Human Peripheral Blood Mononuclear Cell (PBMC) Engraftment of Juvenile Mice
  • 07:29Results: Representative Changes of Viral Load and CD4:CD8 Ratio in huNS -chainnull Mice after HIV Infection and after Anti-retroviral Therapy Introduction
  • 08:41Conclusion

Summary

Automatic Translation

Automatic Translation

Beskrevet her er tre eksperimentelle tilgange til at studere dynamikken i HIV-infektion i humaniserede mus. Den første tillader studiet af kroniske infektions hændelser, mens de to sidstnævnte giver mulighed for undersøgelse af akutte hændelser efter primær infektion eller viral reaktivering.

Tags

Chronic HIV InfectionAcute HIV InfectionReactivated HIV InfectionHumanized Immunodeficient Mouse ModelsNSG Humanized MiceCD34+ Human Stem CellsHepatic InjectionHIV Pre-clinical Studies

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