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JoVE Journal Neuroscience
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain
 

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Article DOI: 10.3791/61119-v • 14:53 min • June 26th, 2020
June 26th, 2020 •
1, 2, 2, 2
1College of Public Health, Shaanxi University of Chinese Medicine, 2Spinal Cord and Brain Injury Research Center, Department of Physiology, University of Kentucky

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Summary
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A method for delivering neural stem cells, adaptable for injecting solutions or suspensions, through the common carotid artery (mouse) or external carotid artery (rat) after ischemic stroke is reported. Injected cells are distributed broadly throughout the brain parenchyma and can be detected up to 30 d after delivery.

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Keywords: Intra-arterial Delivery Neural Stem Cells Cerebral Ischemia Stroke Catheter Design Surgical Hooks Stem Cell Injection GFP-positive Neural Stem Cells
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