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Modellazione di malattie neurodegenerative associate all'età in Caenorhabditis elegans
JoVE Journal
Biology
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JoVE Journal Biology
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
DOI:

07:04 min

August 15, 2020

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Chapters

  • 00:00Introduction
  • 00:39Necrotic Cell Death-induced by Hyperactive Ion Channels
  • 04:06Protein Aggregate-induced Neurodegeneration
  • 05:58Representative Results: Monitor Necrotic Cell Death-Induced by Hyperactive Ion Channels and Protein Aggregate-induced Neurodegeneration
  • 06:30Conclusion

Summary

Automatic Translation

Qui, introduciamo e descriviamo metodologie ampiamente accessibili utilizzando alcuni modelli di nematodi versatili, tra cui la necrosi ionica indotta dal canale ionico e la neurotossicità indotta da aggregazioni proteiche, per monitorare e sezionare le basi cellulari e molecolari delle malattie neurodegenerative associate all'età.

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