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JoVE Journal Neuroscience
Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
 

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Article DOI: 10.3791/61244-v • 06:09 min • November 6th, 2020
November 6th, 2020 •
*1,2, *3, *4, 5, 5, 4, 6, *5, *7
1Geriatrics Research Education and Clinical Center, Veterans Affairs, 2Division of Gerontology and Geriatric Medicine, University of Washington, 3Department of Neurosurgery, University of Florida, 4Department of Neurosurgery, West Virginia University, 5Division of Pharmaceutical Sciences, University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX
* These authors contributed equally

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Summary
Automatic Translation

We present here a protocol of a blast wave model for rodents to investigate neurobiological and pathophysiological effects of mild to moderate traumatic brain injury. We established a gas-driven, bench-top setup equipped with pressure sensors allowing for reliable and reproducible generation of blast-induced mild to moderate traumatic brain injury.

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Keywords: Low-intensity Blast Wave Mild Traumatic Brain Injury Closed-head Injury Acceleration/deceleration Pressure Sensors Shock Tube PVC Pipe Shield Rodent Model Anesthesia Pressure Wave Occipital Condyle
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