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Journal / Biochemistry / A Model Membrane Platform for Reconstituting…
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Biochemistry

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JoVE Journal Biochemistry
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
 

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Article DOI: 10.3791/61620-v • 10:31 min • September 2nd, 2020
September 2nd, 2020 •
1, 1, 2, 1,3
1Department of Molecular Biology, Massachusetts General Hospital, 2Department of Chemistry, University of Akron, 3Department of Genetics, Harvard Medical School

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Summary
Automatic Translation

Mitochondrial fusion is an important homeostatic reaction underlying mitochondrial dynamics. Described here is an in vitro reconstitution system to study mitochondrial inner-membrane fusion that can resolve membrane tethering, docking, hemifusion, and pore opening. The versatility of this approach in exploring cell membrane systems is discussed.

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Keywords: Mitochondria Membrane Dynamics In Vitro Reconstitution Lipid Environment Inner Membrane Fusion Integral Membrane Proteins Membrane-associated Proteins Langmuir-Blodgett Lipid Bilayer Chloroform Sodium Hydroxide Methanol Hydrochloric Acid Polytetrafluoroethylene
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