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1Cardiovascular and Metabolic Sciences, Lerner Research Institute; Women’s Health Institute,Cleveland Clinic, 2Women’s Health Institute,Cleveland Clinic, 3Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center,University of Nebraska Medical Center, 4Anatomic Pathology,Cleveland Clinic, 5Gynecologic Oncology, Women’s Health Institute and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine,Cleveland Clinic
Chapters
- 00:04Introduction
- 00:53Donor and Recipient Mouse Preparation and Donor Mouse Endometrial Tissue Harvest
- 02:59Peritoneal Tissue Fragment Injection
- 04:03Endometriotic Lesion Harvest
- 04:51Endometriotic Lesion Scoring
- 05:58Results: Representative Endometriosis Lesion Histopathological Analyses
- 06:39Conclusion
Mange gnagermodeller av endometriosis er begrenset av teknisk kompleksitet, reproduserbarhet og / eller behov for immunkompromitterte dyr eller spesielle reportermus. Vi presenterer et forenklet system for lesjonsinduksjon ved hjelp av en eksperimentell mus med et uavhengig verifiserbart, objektivt poengsystem og uten krav om ovariektomi eller overlevelseskirurgi.
