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Journal
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Chemistry
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液滴アレイを用いた放射化学反応の最適化
JoVE Journal
Chemistry
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JoVE Journal
Chemistry
Optimization of Radiochemical Reactions using Droplet Arrays
Please note that all translations are automatically generated.
Click here for the English version.
液滴アレイを用いた放射化学反応の最適化
DOI:
10.3791/62056-v
•
10:54 min
•
February 12, 2021
•
Alejandra Rios
2
,
Travis S. Holloway
3
,
Jia Wang
4
,
R. Michael van Dam
2,3,4
1
Physics and Biology in Medicine Interdepartmental Graduate Program
,
University of California Los Angeles (UCLA)
,
2
Crump Institute of Molecular Imaging
,
UCLA
,
3
Department of Molecular & Medical Pharmacology
,
David Geffen School of Medicine
,
4
Department of Bioengineering
,
UCLA
Chapters
00:05
Introduction
01:00
Planning and Optimizing the Study
01:37
Preparation of Reagents and Materials for Optimizing the Radiosynthesis of [
18
F]Fallypride
03:11
Parallel Synthesis of [
18
F]Fallypride with Different Precursor Concentrations
06:02
Synthesis Analysis to Determine Reaction Performance and Optimal Conditions
08:55
Results: Influence of Precursor Concentration on the Microdroplet Synthesis of [
18
F]Fallypride
10:08
Conclusion
Summary
Automatic Translation
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Automatic Translation
本手法は、ナノモル量の試薬を用いた放射性医薬品の迅速かつ経済的最適化のための液滴化学反応に基づく新規ハイスループット方法論の使用を説明する。
Tags
Keywords: Radiochemical Reactions
Droplet Arrays
Automated Radio Synthesizers
FDG
Precursor Concentration
Fallypride
Microdroplet Chips
Photolithography
Thexyl Alcohol
Acetonitrile
Serial Dilutions
Crude Reaction Product
Collection Solution
Fluoride Stock Solution
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