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用于药物发现的人视网膜类器官毒性筛选
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Please note that all translations are automatically generated.
Click here for the English version.
用于药物发现的人视网膜类器官毒性筛选
DOI:
10.3791/62269-v
•
07:45 min
•
March 04, 2021
•
Kevin Eade
2
,
Sarah Giles
2
,
Sarah Harkins-Perry
2
,
Martin Friedlander
2
1
Lowy Medical Research Institute
,
2
The Scripps Research Institute
Chapters
00:04
Introduction
00:47
Deoxysphinganine (deoxySA) Treatment
02:23
Organoid Slice Imaging
03:35
Cell Death Quantification
05:07
Drug Treatment
06:06
Results: Representative Effects of DeoxySA on Retinal Organoid Cell Death
07:03
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在这里,我们提出了一个分步方案来生成成熟的人视网膜类器官,并在光感受器毒性测定中利用它们来确定年龄相关性视网膜退行性疾病黄斑毛细血管扩张症 2 型 (MacTel) 的候选药物。
Tags
Retinal Organoids
Pharmaceutical Discovery
Metabolic Retinal Diseases
MacTel
Fenofibrate
Retinal Degeneration
Toxicity Screens
DeoxySA
Photoreceptor
Cell Death
Preclinical Assay
Cell Culture
Retinal Differentiation
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