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Toksicitetsskærme i humane retinale organoider til farmaceutisk opdagelse
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
DOI:

07:45 min

March 04, 2021

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Chapters

  • 00:04Introduction
  • 00:47Deoxysphinganine (deoxySA) Treatment
  • 02:23Organoid Slice Imaging
  • 03:35Cell Death Quantification
  • 05:07Drug Treatment
  • 06:06Results: Representative Effects of DeoxySA on Retinal Organoid Cell Death
  • 07:03Conclusion

Summary

Automatic Translation

Her præsenterer vi en trinvis protokol til generering af modne humane retinale organoider og udnytter dem i et fotoreceptortoksicitetsassay for at identificere farmaceutiske kandidater til den aldersrelaterede retinale degenerative sygdom makulær telangiectasia type 2 (MacTel).

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