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1Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, 2Chair for Medical Information Technology,RWTH Aachen University
Chapters
- 00:05Introduction
- 00:44The Mechanical Ventilation
- 01:46Introduction of the Pulmonary Artery Catheter
- 02:46Surfactant Depletion
- 03:41Injurious Ventilation with High Tidal Volume/Low PEEP (High Tv/low PEEP)
- 04:25Results: Effects of the Injurious Ventilation on the Lungs
- 05:40Conclusion
A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.
