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JoVE Journal Neuroscience
Modeling Stroke in Mice
 

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Article DOI: 10.3791/62573-v • 07:26 min • May 24th, 2021
May 24th, 2021 •
1, 1, 1,2
1Institute for Stroke and Dementia Research, LMU Munich, 2Munich Cluster for Systems Neurology (SyNergy)

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Summary
Automatic Translation

Different models of middle cerebral artery occlusion (MCAo) are used in experimental stroke research. Here, an experimental stroke model of transient MCAo via the external carotid artery (ECA) is described, which aims to mimic human stroke, in which the cerebrovascular thrombus is removed due to spontaneous clot lysis or therapy.

Tags

Keywords: Transient Middle Cerebral Artery Occlusion External Carotid Artery Filament Model Stroke Model Mouse Surgical Intervention Laser Doppler Common Carotid Artery Dissection Anesthesia Temperature Control Surgical Tools
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