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Journal
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Behavior
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抑郁症的动物模型 - 慢性绝望模型(CDM)
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Behavior
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Behavior
Animal Models of Depression – Chronic Despair Model (CDM)
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抑郁症的动物模型 - 慢性绝望模型(CDM)
DOI:
10.3791/62579-v
•
05:47 min
•
September 23, 2021
•
Stefan Vestring
2
,
Tsvetan Serchov
4
,
Claus Normann
5
1
Department of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Faculty of Medicine
,
University of Freiburg
,
2
Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine
,
University of Freiburg
,
3
Centre National de la Recherche Scientifique (CNRS)
,
Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives
,
4
Department of Stereotactic and Functional Neurosurgery, Medical Center – University Freiburg, Faculty of Medicine
,
University of Freiburg
,
5
Center for Basics in Neuromodulation, Faculty of Medicine
,
University of Freiburg
Chapters
00:04
Introduction
00:57
Induction of the Chronic Despair Model
02:22
Measuring the Immobility Time
03:46
Results: Evaluation of Anti-Depressive Interventions
05:16
Conclusion
Summary
Automatic Translation
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Automatic Translation
抑郁症的慢性绝望小鼠模型(CDM)包括重复的强迫游泳课程和另一个延迟的游泳阶段作为读数。它代表了诱导慢性抑郁样状态稳定至少 4 周的合适模型,可进行修正以评估亚慢性和急性治疗干预。
Tags
Keywords: Animal Models
Depression
Chronic Despair Model
CDM
Chronic Stress
Forced Swim Test
Immobility Time
Antidepressant Evaluation
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