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Biochemistry

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JoVE Journal Biochemistry
Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS)
 

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Article DOI: 10.3791/62732-v • 08:27 min • July 27th, 2021
July 27th, 2021 •
1, 1,2, 1,2
1Max-Planck-Institute of Molecular Plant Physiology, 2Center of Plant Systems Biology and Biotechnology

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Summary
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In this protocol, we present an optimized workflow, which combines an efficient and fast sample preparation of many samples. In addition, we provide a step-by-step guide to reduce analytical variations for high-throughput evaluation of metabolic GWAS studies.

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Keywords: Multi-omics Genome-wide Association Studies Mo-GWAS Sample Preparation Normalization Technical Variation Biological Variance Metabolites Analytical Platform Genotypic Information Phenotypic Information Natural Population Tissue Harvesting Flash Freezing Tissue Homogenization Extraction Centrifugation Solvent Evaporation GCMS UHPLC-MS
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