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Development of a Cell Co-Culture Model to Mimic Cardiac Ischemia/Reperfusion In Vitro
 

Development of a Cell Co-Culture Model to Mimic Cardiac Ischemia/Reperfusion In Vitro

Article DOI: 10.3791/62913-v • 08:05 min • October 13th, 2021
October 13th, 2021 •
1, 1, 1, 1,2,3
1Department of Anesthesiology, Vanderbilt University Medical Center, 2Anesthesiology, TVHS VA Medical Center, 3Department of Pharmacology, Vanderbilt University

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Summary
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Spatial distance is a key parameter in assessing hypoxia/reoxygenation injury in a co-culture model of separate endothelial and cardiomyocyte cell layers, suggesting, for the first time, that optimizing the co-culture spatial environment is necessary to provide a favorable in vitro model for testing the role of endothelial cells in cardiomyocyte protection.

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Keywords: Cell Co-culture Cardiac Ischemia/reperfusion In Vitro Model Cardiomyocyte Endothelial Cell Spatial Environment Cell-cell Interactions Hypoxia Reperfusion Injury Cell Culture Cell Seeding Density Extracellular Matrix
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