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Vurdering L-DOPA-induserte dyskinesier i ensidig 6-OHDA-lesjonert rottemodell av Parkinsons sykdom
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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson’s Disease

Vurdering L-DOPA-induserte dyskinesier i ensidig 6-OHDA-lesjonert rottemodell av Parkinsons sykdom

DOI:
10.3791/62924-v

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06:45 min

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October 04, 2021

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, , ,
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto,University of São Paulo

Chapters

  • 00:04Introduction
  • 00:496-Hydroxydopamine (6-OHDA) Lesion
  • 03:12L-Dopamine (L-DOPA) Chronic Treatment and Abnormal Involuntary Movements (AIMs) Recording and Scoring
  • 05:27Results: The AIMs Patterns in Unilaterally 6-OHDA-Lesioned Rats Chronically Treated with L-DOPA for 3 Weeks
  • 06:16Conclusion

Summary

Automatic Translation

Automatic Translation

Gnagermodeller av L-DOPA-induserte dyskinesier er uvurderlige verktøy for å identifisere terapeutiske inngrep for å dempe utviklingen eller lindre manifestasjonene som oppstår på grunn av gjentatt administrering av L-DOPA. Denne protokollen demonstrerer hvordan man induserer og analyserer dyskinetisk-lignende bevegelser i den ensidige 6-OHDA-lesjonerte rottemodellen av Parkinsons sykdom.

Tags

Keywords: 6-OHDAParkinson’s DiseaseL-DOPA-induced DyskinesiasRat ModelStereotaxic SurgeryStepping TestAbnormal Involuntary Movements

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