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建立大鼠永久性颈静脉插管的显微外科技能，用于口服药物的连续血液采样
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Medicine
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JoVE Journal Medicine
Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
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建立大鼠永久性颈静脉插管的显微外科技能，用于口服药物的连续血液采样

DOI:
10.3791/63167-v

•

08:28 min

•

December 14, 2021

•

, , , , ,
1Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research,Northwestern Polytechnical University

Chapters

  • 00:04Introduction
  • 00:52Jugular Vein Isolation
  • 02:29Jugular Vein Cannulation
  • 04:09Catheter Exteriorization
  • 05:41Physiological and Hematological Monitoring During Recovery Phase
  • 06:41Results: Physiological-Hematological Monitoring and Pharmacokinetics of Ellagic Acid in Jugular Vein Cannulation (JVC) Rat Model
  • 07:48Conclusion

Summary

Automatic Translation

Automatic Translation

详细的显微外科技术被证明可以建立一个长期的颈静脉插管大鼠模型，用于同一动物的序贯血液采集。在大鼠的恢复阶段监测生理和血液学参数。该模型已应用于研究口服多酚的药代动力学，而不会诱导动物应激。

Tags

Jugular Vein CannulationRatMicrosurgeryBlood SamplingPharmaceutical ResearchVein LigationCatheter InsertionHeparinized Saline

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