Journal
/
Cancer Research
/
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
JoVE Journal
Cancer Research
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Cancer Research
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

DOI:
10.3791/63186-v

•

07:41 min

•

March 08, 2022

•

, , , , , , , , ,
1Department of Pathology,NYU Grossman School of Medicine, 2Interdisciplinary Melanoma Cooperative Group,Perlmutter Cancer Center, 3Department of Radiology,NYU Grossman School of Medicine, 4Preclinical Imaging Core,NYU Grossman School of Medicine, 5Ronald Perelman Department of Dermatology,NYU Grossman School of Medicine

Chapters

  • 00:04Introduction
  • 01:14Xenograft Implantation
  • 03:11Staged Survival Surgery and In Vivo Imaging
  • 05:21Nuclear Mitotic Apparatus Protein (NuMA) Staining
  • 05:57Results: Investigation of Potential Actors in Melanoma Metastasis
  • 06:38Conclusion

Summary

Automatic Translation

Automatic Translation

This article describes a workflow of techniques employed for testing novel candidate mediators of melanoma metastasis and their mechanism(s) of action.

Tags

Keywords: Melanoma MetastasisIn Vivo ModelsTarget DiscoveryTherapy DevelopmentIntradermal InjectionIntracardiac InjectionTumor Growth MonitoringUltrasound Guidance

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/63186?article_type=v

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
check_url/63186?article_type=v

A 3D Organotypic Melanoma Spheroid Skin Model
check_url/63186?article_type=v

Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal
check_url/63186?article_type=v

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
check_url/63186?article_type=v

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice
check_url/63186?article_type=v

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
check_url/63186?article_type=v

Enhanced Viability for Ex vivo 3D Hydrogel Cultures of Patient-Derived Xenografts in a Perfused Microfluidic Platform
check_url/63186?article_type=v

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
check_url/63186?article_type=v

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
check_url/63186?article_type=v

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Read Article