Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Osmotic Pump-based Drug-delivery for In Vivo…
JoVE Journal
Neuroscience

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Neuroscience
Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
 

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Article DOI: 10.3791/63343-v • 06:07 min • December 17th, 2021
December 17th, 2021 •
1, 1,2, 1,3, 1
1Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain, and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, 2Research Centre, The Seventh Affiliated Hospital of Sun Yat-sen University, 3School of Medicine, Chongqing University

Chapters

Summary
Automatic Translation

Demyelination takes place in multiple central nervous system diseases. A reliable in vivo drug delivery technique is necessary for remyelinating drug testing. This protocol describes an osmotic pump-based method that allows long-term drug delivery directly into the brain parenchyma and improves the drug bioavailability, with broad application in remyelination research.

Tags

Keywords: Osmotic Pump Drug Delivery Remyelination Central Nervous System Blood-brain Barrier Lysolecithin Brain Infusion Drug Administration
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter