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改善肾去神经支配缓解血管紧张素II.诱导的高血压

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Medicine

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JoVE Journal Medicine

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

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改善肾去神经支配缓解血管紧张素II.诱导的高血压

DOI:

10.3791/63719-v

•

08:35 min

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May 26, 2022

•

Ming Wang*^1,2, Shuyi Zhang*^1,2, Wanling Han², Maoqing Ye², Xinkai Qu², Wenzheng Han²

¹Department of Cardiology,Huadong Hospital Affiliated to Fudan University, ²Shanghai Key Laboratory of Clinical Geriatric Medicine

Chapters

00:05Introduction
00:42Preparation of the Operation Field
01:18Angiotensin II Induced Hypertension
03:21Bilateral Renal Denervation
05:33Results: Renal Sympathetic Denervation (RDN) in Mice with Hypertension Induced by Angiotensin II Infusion
07:41Conclusion

Summary

Automatic Translation

在这里，我们提出了由血管紧张素II输注诱导的高血压小鼠肾交感神经去神经支配（RDN）的方案。该程序可重复，方便，并允许研究RDN对高血压和心脏肥大的调节机制。

Tags

Keywords: Renal Denervation Hypertension Angiotensin II Infusion Osmotic Pump Tail-cuff Plethysmography Surgical Procedure C57BKL/6 Mouse Blood Pressure Monitoring

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