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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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JoVE Journal Chemistry
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

DOI:
10.3791/63993-v

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11:27 min

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August 09, 2022

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, ,
1Research Center Pharmaceutical Engineering,GmbH, 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy,University of Graz

Chapters

  • 00:04Introduction
  • 01:03Differential Scanning Calorimetry (DSC): Instrument Preparation
  • 02:25Differential Scanning Calorimetry (DSC): Sample Preparation and Measurement
  • 03:00Differential Scanning Calorimetry (DSC): Data Analysis
  • 04:38Small and Wide-Angle X-Ray Scattering (SWAXS)
  • 08:11Results: Correlation Between Solid State Alteration of Lipids and API Release from Different Lipid-Based Dosage Forms
  • 10:39Conclusion

Summary

Automatic Translation

Automatic Translation

This publication shows the application of x-ray diffraction and differential scanning calorimetry as gold standards for investigating the solid-state of lipid-based excipients (LBEs). Understanding the solid-state alteration in LBEs and its effect on the performance of pharmaceutical products thereof is the key factor for manufacturing robust lipid-based dosage forms.

Tags

Keywords: Differential Scanning CalorimetryDSCX-ray DiffractionLipid-based PharmaceuticalsPolymorphismCrystal GrowthSolid-state AlterationLipid MatrixNano Lipid FormulationsMatrix TabletsTemperature ModulationHeating CycleCooling CycleCalibrationSample PreparationAuto Sampler

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