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Journal / Bioengineering / Isolation of Next-Generation Gene Therapy Vectors …
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Bioengineering

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JoVE Journal Bioengineering
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants
 

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Article DOI: 10.3791/64389-v • 09:20 min • October 18th, 2022
October 18th, 2022 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3,4,5
1Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, 2BioQuant Center, BQ0030, University of Heidelberg, 3Cluster of Excellence CellNetworks, 4German Center for Infection Research (DZIF), 5German Center for Cardiovascular Research (DZHK)

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Summary
Automatic Translation

AAV peptide display library generation and subsequent validation through the barcoding of candidates with novel properties for the creation of next-generation AAVs.

Tags

Keywords: Adeno-associated Virus (AAV) Gene Therapy Capsid Engineering High-throughput Screening Next-generation Sequencing (NGS) Bioinformatics Python Biopython
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