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Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
JoVE Journal
Medicine
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JoVE Journal Medicine
Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
DOI:

05:03 min

October 28, 2022

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Chapters

  • 00:00Introduction
  • 00:35Silica Preparation
  • 01:11Silica Exposure to the Rats
  • 03:28Results: Characterization of the Silicotic Nodules
  • 04:46Conclusion

Summary

Automatic Translation

This study describes a technique to establish a silicosis rat model with the inhalation of silica through the whole body in an inhalation chamber. The rats with silicosis could closely mimic the pathological process of human silicosis in an easy, cost-effective manner with good repeatability.

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