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全层软骨缺损大鼠模型的开发与评价

JoVE Journal
Medicine

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JoVE Journal Medicine

Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects

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全层软骨缺损大鼠模型的开发与评价

DOI:

10.3791/64475-v

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04:34 min

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May 19, 2023

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Haiyan Zhang*¹, Ronghua Bao*², Jiaan Xu, Yanzhi Ge, Zuxiang Chen, Mengqiang Fan, Guangping Yu, Li Zhou, Le Guo, Letian Shan, Hangxing Bao

¹The First Affiliated Hospital,Zhejiang Chinese Medical University, ²Fuyang Orthopaedics and Traumatology Affiliated Hospital,Zhejiang Chinese Medical University, ³College of Pharmaceutical Science,Zhejiang Chinese Medical University, ⁴Affiliated Zhejiang Hospital,Zhejiang University School of Medicine, ⁵Xianju County Hospital of Chinese Medicine

Chapters

00:04Introduction
01:18Establishment of Murine Full‐Thickness Cartilage Defects Model
02:27Measurement of Mechanical Withdrawal Threshold
03:12Results: Comparative Analysis of Mechanical Withdrawal Threshold in Murine Models
04:10Conclusion

Summary

Automatic Translation

该协议通过在大鼠的股骨滑车沟中钻孔并测量随后的疼痛行为和组织病理学变化来建立全层软骨缺陷（FTCD）模型。

Tags

Rat Model Full-thickness Cartilage Defects FTCD Traumatic Cartilage Defects Post-traumatic Osteoarthritis Cartilage Injury Animal Model Cartilage Defect Evaluation Mechanical Withdrawal Threshold Hyperalgesia

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