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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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JoVE Journal Cancer Research
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

DOI:
10.3791/64544-v

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13:41 min

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January 13, 2023

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, , , , , , , , , , , , , ,
1Institute of Medical Science,University of Toronto, 2Lunenfeld-Tanenbaum Research Institute,Mount Sinai Hospital, 3The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention,The Hospital for Sick Children, 4Institute of Biomedical Engineering,University of Toronto, 5Leslie Dan Faculty of Pharmacy,University of Toronto, 6Departments of Radiology and Clinical Neurosciences,University of Calgary, 7Department of Radiation Oncology,University of Toronto, 8Department of Medical Imaging,University of Toronto, 9Department of Pediatric Surgery,University of Toronto, 10Department of Surgery,University of Toronto

Chapters

  • 00:04Introduction
  • 01:11Intramuscular Cell Injection
  • 02:08Screening MRI Scan and HIFU Treatment
  • 10:46Results: Average Temperatures and Success Rates of Hyperthermia Treatment and Doxorubicin Levels in the Tumor
  • 13:03Conclusion

Summary

Automatic Translation

Automatic Translation

Presented here is a protocol to use controlled hyperthermia, generated by magnetic resonance-guided high intensity focused ultrasound, to trigger drug release from temperature-sensitive liposomes in a rhabdomyosarcoma mouse model.

Tags

Magnetic ResonanceHigh Intensity Focused UltrasoundHyperthermiaRhabdomyosarcomaPreclinical TestingTumor TargetedThermosensitive DrugsSarcomaLocalized HypothermiaImmune SystemMRIHIFUMouse ModelTumor GrowthImagingTransducerDeionized WaterAnesthesia

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