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前药染料纳米组件的简单制备和光活化

JoVE Journal
Medicine

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JoVE Journal Medicine

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

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前药染料纳米组件的简单制备和光活化

DOI:

10.3791/64677-v

•

08:54 min

•

February 17, 2023

•

Yichi Zhang^2,3, Kaiqi Long^2,3, Weiping Wang^2,3

¹State Key Laboratory of Pharmaceutical Biotechnology,The University of Hong Kong, ²Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine,The University of Hong Kong, ³Laboratory of Molecular Engineering and Nanomedicine, Dr. Li Dak-Sum Research Centre,The University of Hong Kong

Chapters

00:04Introduction
00:37Preparation of IR783/BC Nanoparticles by the Flash Precipitation Method
02:52Characterization of IR783/BC Nanoparticles
04:47Photoactivation of IR783/BC Nanoparticles
06:24Results: Fabrication and Characterization of a Photoresponsive Prodrug-Dye Nano Assembly
08:27Conclusion

Summary

Automatic Translation

该协议描述了光响应前药染料纳米组装的制造和表征。明确描述了通过光触发拆卸从纳米颗粒释放药物的方法，包括光照射设置。光照射后从纳米颗粒释放的药物对人结直肠肿瘤细胞表现出优异的抗增殖作用。

Tags

Prodrug-dye Nanoassemblies Photoactivation Drug Delivery Colorectal Tumor Boron Dipyrromethene Chlorambucil IR783 Nanoparticle Fabrication Encapsulation Efficiency Loading Capacity Dynamic Light Scattering Surface Charge

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