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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

DOI:
10.3791/64801-v

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08:47 min

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March 03, 2023

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, ,
1Department of Clinical Immunology,Wroclaw Medical University, 2ALL-MED Medical Research Institute

Chapters

  • 00:04Introduction
  • 01:03Cleaning the AEC
  • 02:26Operating the AEC: Environment
  • 03:10Generation and Counting of Particles
  • 03:45Examination in the Cabin and Clinical Endpoints
  • 06:45Results: Stability of the Environment in the AEC During the Trial and Different Endpoints During the AEC Challenge in Patients
  • 08:01Conclusion

Summary

Automatic Translation

Automatic Translation

A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental conditions.

Tags

Keywords: Allergen Exposure ChamberAllergenNasal ObstructionNasal SecretionAllergen-specific ImmunotherapyPharmacotherapyAllergic Respiratory DiseasesVacuumAir FilterAir CirculationTemperature ControlHumidity ControlCarbon Dioxide ControlLaser Particle CounterParticle Size Monitoring

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