Evaluating Quantitative Tumor Cell Killing by CAR-Expressing Jurkat Cells

October 27th, 2023

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Siddharth Subham*^1,2,3, John D. Jeppson*¹, Benjamin K. Gibbs⁴, Jacqueline Babai², Riza Alker¹, Andrew K. Godwin^4,5,6, David Akhavan^1,2,3

¹Department of Radiation Oncology, University of Kansas Cancer Center, ²Department of Cancer Biology, University of Kansas Cancer Center, ³BioEngineering Program, University of Kansas, ⁴Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, ⁵University of Kansas Cancer Center, ⁶Kansas Institute for Precision Medicine, University of Kansas Medical Center

* These authors contributed equally

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פרוטוקול להערכת הרג כמותי של תאי גידול על ידי תאי Jurkat המבטאים קולטן אנטיגן כימרי (CAR) המכוון לאנטיגן גידול יחיד. פרוטוקול זה יכול לשמש כפלטפורמת סינון לאופטימיזציה מהירה של מבני צירי CAR לפני אישור בתאי T היקפיים שמקורם בדם.

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Evaluating Quantitative Tumor Cell Killing by CAR-Expressing Jurkat Cells

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