C. David Weaver Department of Pharmacology Vanderbilt University School of Medicine Biography Publications Institution JoVE Articles C. David Weaver has not added a biography. If you are C. David Weaver and would like to personalize this page please email our Author Liaison for assistance. Publications Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database Molecules (Basel, Switzerland). 2013 | Pubmed ID: 23299552 Nonoisotopic Assay for the Presynaptic Choline Transporter Reveals Capacity for Allosteric Modulation of Choline Uptake ACS Chemical Neuroscience. Oct, 2012 | Pubmed ID: 23077721 Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à -go-go-related Gene (hERG)-related Drug-induced Arrhythmias The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23033485 Optimization of an Ether Series of MGlu5 Positive Allosteric Modulators: Molecular Determinants of MPEP-site Interaction Crossover Bioorganic & Medicinal Chemistry Letters. Oct, 2012 | Pubmed ID: 22981332 Further Optimization of the K-Cl Cotransporter KCC2 Antagonist ML077: Development of a Highly Selective and More Potent in Vitro Probe Bioorganic & Medicinal Chemistry Letters. Jul, 2012 | Pubmed ID: 22727639 A Biased Ligand for OXE-R Uncouples Gα and Gβγ Signaling Within a Heterotrimer Nature Chemical Biology. Jul, 2012 | Pubmed ID: 22634634 Iterative Experimental and Virtual High-throughput Screening Identifies Metabotropic Glutamate Receptor Subtype 4 Positive Allosteric Modulators Journal of Molecular Modeling. Sep, 2012 | Pubmed ID: 22592386 Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function Molecular Pharmacology. Feb, 2012 | Pubmed ID: 22021324 The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease ACS Chemical Neuroscience. Dec, 2011 | Pubmed ID: 22368764 Discovery, Characterization, and Structure-activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.x, and Kir7.1 Frontiers in Pharmacology. 2011 | Pubmed ID: 22275899 Discovery, Synthesis, and Structure-activity Relationship Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu(4)) with Oral Efficacy in an Antiparkinsonian Animal Model Journal of Medicinal Chemistry. Nov, 2011 | Pubmed ID: 21966889 Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21795696 High-throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins Analytical Chemistry. Sep, 2011 | Pubmed ID: 21770391 Solution-phase Parallel Synthesis and SAR of Homopiperazinyl Analogs As Positive Allosteric Modulators of MGluâ‚„ ACS Combinatorial Science. Mar, 2011 | Pubmed ID: 21338051 Synthesis and SAR of Centrally Active MGlu5 Positive Allosteric Modulators Based on an Aryl Acetylenic Bicyclic Lactam Scaffold Bioorganic & Medicinal Chemistry Letters. Mar, 2011 | Pubmed ID: 21315585 Development of a High Throughput Screen for Allosteric Modulators of Melanocortin-4 Receptor Signaling Using a Real Time CAMP Assay European Journal of Pharmacology. Jun, 2011 | Pubmed ID: 21296065 Discovery, Synthesis, and Structure-activity Relationship Development of a Series of N-(4-acetamido)phenylpicolinamides As Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu(4)) with CNS Exposure in Rats Journal of Medicinal Chemistry. Feb, 2011 | Pubmed ID: 21247167 Identification and Optimization of Small Molecules That Restore E-cadherin Expression and Reduce Invasion in Colorectal Carcinoma Cells ACS Chemical Biology. May, 2011 | Pubmed ID: 21241068 Discovery and Optimization of a Novel, Selective and Brain Penetrant M1 Positive Allosteric Modulator (PAM): the Development of ML169, an MLPCN Probe Bioorganic & Medicinal Chemistry Letters. May, 2011 | Pubmed ID: 21194936 Development of a Selective Small-molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel Molecular Pharmacology. Jan, 2011 | Pubmed ID: 20926757 Discovery of N-Aryl Piperazines As Selective MGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity ACS Medicinal Chemistry Letters. Nov, 2010 | Pubmed ID: 23308336 Discovery and Characterization of Novel Subtype-selective Allosteric Agonists for the Investigation of M(1) Receptor Function in the Central Nervous System ACS Chemical Neuroscience. 2010 | Pubmed ID: 21961051 Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and in Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity Molecular Pharmacology. Dec, 2010 | Pubmed ID: 20923853 Synthesis and SAR of Novel, 4-(phenylsulfamoyl)phenylacetamide MGlu4 Positive Allosteric Modulators (PAMs) Identified by Functional High-throughput Screening (HTS) Bioorganic & Medicinal Chemistry Letters. Sep, 2010 | Pubmed ID: 20667732 Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening ACS Chemical Neuroscience. Apr, 2010 | Pubmed ID: 20414370 Context-dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7 Molecular Pharmacology. Mar, 2010 | Pubmed ID: 20026717 MAOS Ls for the General Synthesis and Lead Optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines Tetrahedron Letters. Jan, 2009 | Pubmed ID: 22090663 Synthesis and SAR of Novel, Non-MPEP Chemotype MGluR5 NAMs Identified by Functional HTS Bioorganic & Medicinal Chemistry Letters. Dec, 2009 | Pubmed ID: 19875287 Discovery and SAR of 6-substituted-4-anilinoquinazolines As Non-competitive Antagonists of MGlu5 Bioorganic & Medicinal Chemistry Letters. Dec, 2009 | Pubmed ID: 19854049 Discovery and Development of a Potent and Highly Selective Small Molecule Muscarinic Acetylcholine Receptor Subtype I (mAChR 1 or M1) Antagonist in Vitro and in Vivo Probe Current Topics in Medicinal Chemistry. 2009 | Pubmed ID: 19807667 High-throughput Screening Reveals a Small-molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1 Molecular Pharmacology. Nov, 2009 | Pubmed ID: 19706730 Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs) Journal of Medicinal Chemistry. Jul, 2009 | Pubmed ID: 19469556 Discovery and SAR of Novel MGluR5 Non-competitive Antagonists Not Based on an MPEP Chemotype Bioorganic & Medicinal Chemistry Letters. Jun, 2009 | Pubmed ID: 19443219 Discovery of the First Highly M5-preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-trifluoromethoxy N-benzyl Isatins Journal of Medicinal Chemistry. Jun, 2009 | Pubmed ID: 19438238 Small-molecule Screen Identifies Inhibitors of the Neuronal K-Cl Cotransporter KCC2 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19279215 Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity Molecular Pharmacology. Mar, 2009 | Pubmed ID: 19047481 Preliminary SAR Studies on Non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) Channel Blockers Bioorganic & Medicinal Chemistry Letters. Oct, 2008 | Pubmed ID: 18824351 Initial SAR Studies on Apamin-displacing 2-aminothiazole Blockers of Calcium-activated Small Conductance Potassium Channels Bioorganic & Medicinal Chemistry Letters. Oct, 2008 | Pubmed ID: 18774291 Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 Molecular Pharmacology. Nov, 2008 | Pubmed ID: 18664603 A Novel Assay of Gi/o-linked G Protein-coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors Molecular Pharmacology. Apr, 2008 | Pubmed ID: 18171729 A Novel High-throughput PepT1 Transporter Assay Differentiates Between Substrates and Antagonists Molecular Pharmaceutics. Jan, 2004 | Pubmed ID: 15832502 A Thallium-sensitive, Fluorescence-based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian Cells Journal of Biomolecular Screening. Dec, 2004 | Pubmed ID: 15634793 Высокопроизводительного скрининга для малых молекул модуляторы калиевых каналов входящего Rectifier Rene Raphemot1,2, C. David Weaver1,3, Jerod S. Denton1,2 1Department of Pharmacology, Vanderbilt University School of Medicine, 2Department of Anesthesiology, Vanderbilt University School of Medicine, 3Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine JoVE 4209 Biology
Высокопроизводительного скрининга для малых молекул модуляторы калиевых каналов входящего Rectifier Rene Raphemot1,2, C. David Weaver1,3, Jerod S. Denton1,2 1Department of Pharmacology, Vanderbilt University School of Medicine, 2Department of Anesthesiology, Vanderbilt University School of Medicine, 3Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine JoVE 4209 Biology