Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation Nature Medicine. Oct, 2019 | Pubmed ID: 31591597 Herceptin: A First Assault on Oncogenes That Launched a Revolution Cell. Sep, 2019 | Pubmed ID: 31519311 FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes Nature. 07, 2019 | Pubmed ID: 31243370 Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. Jul, 2019 | Pubmed ID: 31152158 Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31061129 Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance ELife. Jan, 2019 | Pubmed ID: 30644358 Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade JAMA Oncology. Apr, 2019 | Pubmed ID: 30589920 SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019 | Pubmed ID: 30587545 Strategies to Identify and Target Cells of Origin in Prostate Cancer Journal of the National Cancer Institute. Mar, 2019 | Pubmed ID: 30312421 American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives JCO Clinical Cancer Informatics. 12, 2018 | Pubmed ID: 30652542 Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer The Journal of Clinical Investigation. 10, 2018 | Pubmed ID: 30179225 Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death ELife. 09, 2018 | Pubmed ID: 30178746 Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 30109253 Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes Nature Communications. 06, 2018 | Pubmed ID: 29921838 The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. 05, 2018 | Pubmed ID: 29610475 Challenges in Validating Candidate Therapeutic Targets in Cancer ELife. 02, 2018 | Pubmed ID: 29417929 Targeting DNA Repair in Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018 | Pubmed ID: 29369701 Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting European Urology. 05, 2018 | Pubmed ID: 29258679 Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer JAMA Oncology. Feb, 2018 | Pubmed ID: 29121144 Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis Nature Communications. 10, 2017 | Pubmed ID: 29057879 Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer ELife. 09, 2017 | Pubmed ID: 28891793 Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing JAMA. 09, 2017 | Pubmed ID: 28873162 Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making JCO Precision Oncology. Jul, 2017 | Pubmed ID: 28825054 ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis Nature. 06, 2017 | Pubmed ID: 28614298 Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions The New England Journal of Medicine. 05, 2017 | Pubmed ID: 28538124 SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059768 Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059767 Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell Reports. 12, 2016 | Pubmed ID: 27926864 A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon PloS One. 2016 | Pubmed ID: 27536883 Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data Nature Medicine. 05, 2016 | Pubmed ID: 27149219 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins Molecular Pharmaceutics. Feb, 2016 | Pubmed ID: 26725682 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer Nature Reviews. Cancer. Dec, 2015 | Pubmed ID: 26563462 All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health Cancer Discovery. Nov, 2015 | Pubmed ID: 26526696 Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation Cancer Research. Nov, 2015 | Pubmed ID: 26432404 Identification of an Oncogenic RAB Protein Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26338797 Integrative Clinical Genomics of Advanced Prostate Cancer Cell. May, 2015 | Pubmed ID: 26000489 Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ Cancer Cell. Jan, 2015 | Pubmed ID: 25544636 Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling Molecular Cancer Therapeutics. Jan, 2015 | Pubmed ID: 25381262 MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271328 Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries Molecular Imaging. 2014 | Pubmed ID: 25248353 Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 25204554 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma Genes & Development. Aug, 2014 | Pubmed ID: 25128497 Copy Number Alteration Burden Predicts Prostate Cancer Relapse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25024180 Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade Cell. Dec, 2013 | Pubmed ID: 24315100 "N of 1" Case Reports in the Era of Whole-genome Sequencing The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135144 Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers Cancer Discovery. Nov, 2013 | Pubmed ID: 24027196 Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013 | Pubmed ID: 24002508 ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss Nature Medicine. Aug, 2013 | Pubmed ID: 23817021 Perspective: Combined Forces Nature. Jun, 2013 | Pubmed ID: 23803949 Developing Standards for Breakthrough Therapy Designation in Oncology Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23719260 Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design ELife. Apr, 2013 | Pubmed ID: 23580326 β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348745 Proyección De Imagen Carga Del Tumor En El Cerebro Con 89Zr-transferrina Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013 | Pubmed ID: 23236019 The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs Transactions of the American Clinical and Climatological Association. 2012 | Pubmed ID: 23303979 Annotating MYC Status with 89Zr-transferrin Imaging Nature Medicine. Oct, 2012 | Pubmed ID: 23001181 Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors Cancer Research. Dec, 2012 | Pubmed ID: 22971343 JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753496 Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen Cancer Discovery. Apr, 2012 | Pubmed ID: 22576209 Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening PloS One. 2012 | Pubmed ID: 22509301 Converting Cancer Therapies into Cures: Lessons from Infectious Diseases Cell. Mar, 2012 | Pubmed ID: 22424221 ARN-509: Un Antiandrógeno Novedosa Para El Tratamiento De Cáncer De Próstata Cancer Research. Jan, 2012 | Pubmed ID: 22266222 Aptitud Conferida Por Mutaciones De Dominio Quinasa BCR-ABL Determina El Riesgo De Resistencia Preexistente En Leucemia Mieloide Crónica PloS One. 2011 | Pubmed ID: 22140458 Estado De TMPRSS2-ERG En La Circulación De Las Células Tumorales Como Un Biomarcador Predictivo De Sensibilidad En Los Pacientes De Cáncer De Próstata Resistente a La Castración Tratados Con Acetato De Abiraterona European Urology. Nov, 2011 | Pubmed ID: 21802835 Medición No Invasiva Del Receptor Del Andrógeno De Señalización Con Un Radiofármaco Emisor De Positrones Ese Antígeno Prostático Específico De Membrana De Objetivos Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 Regulación Recíproca Retroalimentación Del Receptor PI3K Y Andrógenos En Cáncer De Próstata De PTEN Deficientes Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS Y Señalización NF-κB Modulan Dependencia De Cánceres De Pulmón Mutante EGFR Nature. Mar, 2011 | Pubmed ID: 21430781 MYC Coopera Con AKT En Tumorigenesis Próstata Y Altera La Sensibilidad a Los Inhibidores De MTOR PloS One. 2011 | Pubmed ID: 21394210 ETV1 Es Un Factor De Supervivencia Linaje Que Coopera Con Tumores Gastrointestinales En El KIT Del Estroma Nature. Oct, 2010 | Pubmed ID: 20927104 Variantes De Empalme De Receptor De Andrógeno Constitutivamente Activa Expresadas En Cáncer De Próstata Resistente a La Castración Requieren Receptor Del Andrógeno De Larga Duración Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 Perfiles Genómicos Integradora De Cáncer De Próstata Humano Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 Coordinar La Regulación Transcripcional Del Receptor ERG Y Andrógenos En Cánceres De Próstata De Fusión-positivo Cancer Cell. May, 2010 | Pubmed ID: 20478521 Actividad Antitumoral De MDV3100 En Cáncer De Próstata Resistente a La Castración: Un Estudio De Fase 1-2 Lancet. Apr, 2010 | Pubmed ID: 20398925 Relación Estructura-actividad De Thiohydantoin Antagonistas De Receptores De Andrógenos Para El Cáncer De Próstata Resistente a La Castración (CRPC) Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 Hematopoyesis Clonal En Células De Médula Cromosoma-negativa De Philadelphia De Pacientes De Leucemia Mieloide Crónica Recibir Dasatinib Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 Lecciones Aprendieron En El Desarrollo De Inhibidores De La Cinasa Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 Cambio De Paradigmas: Las Semillas De La Adicción De Oncogén Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 Proteasomal E Inactivación Genética Del Supresor Del Tumor De NF1 En Gliomagenesis Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 Encontrar Y Drogando Las Vulnerabilidades De Cánceres RAS-dependientes Cell. May, 2009 | Pubmed ID: 19490885 Cooperatividad De TMPRSS2-ERG Con Activación Vía De PI3-quinasa En Próstata Oncogénesis Nature Genetics. May, 2009 | Pubmed ID: 19396167 Desarrollo De Un Antiandrógeno De Segunda Generación Para El Tratamiento De Cáncer De Próstata Avanzado Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 Histona Desacetilasas Son Necesarios Para La Función Del Receptor De Andrógenos En El Cáncer De Próstata Hormona-sensible Y Resistente a La Castración Cancer Research. Feb, 2009 | Pubmed ID: 19176386 ¿Investigación Traslacional: Estamos En El Camino Correcto? 2008 Sociedad Americana Para La Investigación Clínica Discurso Presidencial The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 La Vía Del Factor Nuclear Kappa B Controla La Progresión Del Cáncer De Próstata Al Crecimiento Andrógeno-independiente Cancer Research. Aug, 2008 | Pubmed ID: 18701501 Un Puesto De Control De Kip1 De P27 De Dependiente De Neoplasia Intraepitelial Prostática Induce La Senescencia E Inhibe La Proliferación Celular Y La Progresión Del Cáncer Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 Dirige a La Vía Del Receptor De Andrógenos En El Cáncer De Próstata Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 El Problema De Biomarcadores Del Cáncer Nature. Apr, 2008 | Pubmed ID: 18385728 Algo Perdido--algo Ganado: El ASCI Comienza Su Segundo Siglo The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 Actividad Antitumoral De La Rapamicina En Una Fase Que Prueba Para Los Pacientes Con Glioblastoma Recurrente De PTEN Deficientes PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 Terapia Secuencial De Inhibidor De La Cinasa ABL Selecciona Para Las Mutaciones De BCR-ABL Farmacorresistentes Compuestas Con Potencia Oncogénico Alterada The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 Fosforilación Del Lazo De Unión a ATP Dirige Oncogenicity De Mutantes Resistentes a Los Fármacos De BCR-ABL Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 Biología Del Cáncer De Próstata Resistente a La Castración, Progresivo: Dirigido a Terapias Dirigidas Al Eje De Señalización Del Receptor De Andrógenos Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 Inhibición De Mutantes Resistentes a Los Fármacos De Quinasas Del Receptor De EGF, ABL Y KIT Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 Un Inhibidor De La Pyridopyrimidine Novela De Abl Quinasa Es Un Picomolar Inhibidor De Las Células K562 Bcr-abl-conducido Y Es Eficaz Contra Los Mutantes Resistentes a STI571 Bcr-abl Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 Cultivos organoides de próstata como herramientas para traducir genotipos y perfiles mutacionales a respuestas farmacológicas Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research
Cultivos organoides de próstata como herramientas para traducir genotipos y perfiles mutacionales a respuestas farmacológicas Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research