Charles O. Rock Department of Infectious Diseases St. Jude Children's Research Hospital Biography Publications Institution JoVE Articles Charles O. Rock has not added a biography. If you are Charles O. Rock and would like to personalize this page please email our Author Liaison for assistance. Publications A Fatty Acid Binding Protein of Facilitates the Acquisition of Host Polyunsaturated Fatty Acids The Journal of Biological Chemistry. Sep, 2019 | Pubmed ID: 31530637 Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus Aureus MBio. Aug, 2019 | Pubmed ID: 31387906 Oleate Hydratase from Protects Against Palmitoleic Acid, the Major Antimicrobial Fatty Acid Produced by Mammalian Skin The Journal of Biological Chemistry. Jun, 2019 | Pubmed ID: 31018965 Human Pantothenate Kinase 4 is a Pseudo-pantothenate Kinase Protein Science : a Publication of the Protein Society. Jun, 2019 | Pubmed ID: 30927326 Acyl-chain Selectivity and Physiological Roles of Fatty Acid-binding Proteins The Journal of Biological Chemistry. 01, 2019 | Pubmed ID: 30429218 A Therapeutic Approach to Pantothenate Kinase Associated Neurodegeneration Nature Communications. 10, 2018 | Pubmed ID: 30352999 Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis Frontiers in Microbiology. 2018 | Pubmed ID: 30319589 The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase Frontiers in Microbiology. 2018 | Pubmed ID: 30065703 Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in MBio. 08, 2017 | Pubmed ID: 28765222 A Two-helix Motif Positions the Lysophosphatidic Acid Acyltransferase Active Site for Catalysis Within the Membrane Bilayer Nature Structural & Molecular Biology. Aug, 2017 | Pubmed ID: 28714993 Exogenous Fatty Acid Metabolism in Bacteria Biochimie. Oct, 2017 | Pubmed ID: 28668270 Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation Cell Reports. 06, 2017 | Pubmed ID: 28591579 Excess Coenzyme A Reduces Skeletal Muscle Performance and Strength in Mice Overexpressing Human PANK2 Molecular Genetics and Metabolism. 04, 2017 | Pubmed ID: 28189602 T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions The Journal of Biological Chemistry. Jan, 2017 | Pubmed ID: 27903651 Bacterial Fatty Acid Metabolism in Modern Antibiotic Discovery Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Nov, 2017 | Pubmed ID: 27668701 Pyruvate Oxidase As a Critical Link Between Metabolism and Capsule Biosynthesis in Streptococcus Pneumoniae PLoS Pathogens. Oct, 2016 | Pubmed ID: 27760231 Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria Monocytogenes Infection and Immunity. Dec, 2016 | Pubmed ID: 27736774 Allosteric Regulation of Mammalian Pantothenate Kinase The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27555321 A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome Antimicrobial Agents and Chemotherapy. 07, 2016 | Pubmed ID: 27161626 Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics Cold Spring Harbor Perspectives in Medicine. Mar, 2016 | Pubmed ID: 26931811 Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26774272 Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria The Journal of Biological Chemistry. Jan, 2016 | Pubmed ID: 26567338 Correction of a Genetic Deficiency in Pantothenate Kinase 1 Using Phosphopantothenate Replacement Therapy Molecular Genetics and Metabolism. Dec, 2015 | Pubmed ID: 26549575 Maternal Bile Acid Transporter Deficiency Promotes Neonatal Demise Nature Communications. Sep, 2015 | Pubmed ID: 26416771 Chlamydia Trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis Via an Acyl-Acyl Carrier Protein Synthetase The Journal of Biological Chemistry. Sep, 2015 | Pubmed ID: 26195634 Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay Antimicrobial Agents and Chemotherapy. Sep, 2015 | Pubmed ID: 26169404 Chlamydia Trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 25995447 How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648887 A High-throughput Screen Reveals New Small-molecule Activators and Inhibitors of Pantothenate Kinases Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25569308 A Thioesterase Bypasses the Requirement for Exogenous Fatty Acids in the PlsX Deletion of Streptococcus Pneumoniae Molecular Microbiology. Apr, 2015 | Pubmed ID: 25534847 FabH Mutations Confer Resistance to FabF-directed Antibiotics in Staphylococcus Aureus Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25403676 Identification of a Two-component Fatty Acid Kinase Responsible for Host Fatty Acid Incorporation by Staphylococcus Aureus Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002480 Type II Fatty Acid Synthesis is Essential for the Replication of Chlamydia Trachomatis The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24958721 Pank1 Deletion in Leptin-deficient Mice Reduces Hyperglycaemia and Hyperinsulinaemia and Modifies Global Metabolism Without Affecting Insulin Resistance Diabetologia. Jul, 2014 | Pubmed ID: 24781151 Discovery of Novel Bacterial Elongation Condensing Enzyme Inhibitors by Virtual Screening Bioorganic & Medicinal Chemistry Letters. Jun, 2014 | Pubmed ID: 24755430 Incorporation of Extracellular Fatty Acids by a Fatty Acid Kinase-dependent Pathway in Staphylococcus Aureus Molecular Microbiology. Apr, 2014 | Pubmed ID: 24673884 The Identification, Analysis and Structure-based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin Pyrophosphokinase Bioorganic & Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24613625 Phosphatidylglycerol Homeostasis in Glycerol-phosphate Auxotrophs of Staphylococcus Aureus BMC Microbiology. Nov, 2013 | Pubmed ID: 24238430 Resistance to AFN-1252 Arises from Missense Mutations in Staphylococcus Aureus Enoyl-acyl Carrier Protein Reductase (FabI) The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24189061 Staphylococcus Aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice Antimicrobial Agents and Chemotherapy. Nov, 2013 | Pubmed ID: 23979734 Bacterial Lipids: Metabolism and Membrane Homeostasis Progress in Lipid Research. Jul, 2013 | Pubmed ID: 23500459 Perturbation of Staphylococcus Aureus Gene Expression by the Enoyl-acyl Carrier Protein Reductase Inhibitor AFN-1252 Antimicrobial Agents and Chemotherapy. May, 2013 | Pubmed ID: 23459481 Preface: Phospholipids and Phospholipid Metabolism Biochimica Et Biophysica Acta. Mar, 2013 | Pubmed ID: 23369660 Phosphatidic Acid Synthesis in Bacteria Biochimica Et Biophysica Acta. Mar, 2013 | Pubmed ID: 22981714 Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1 Cell Host & Microbe. Sep, 2012 | Pubmed ID: 22980328 Membrane Disruption by Antimicrobial Fatty Acids Releases Low-molecular-weight Proteins from Staphylococcus Aureus Journal of Bacteriology. Oct, 2012 | Pubmed ID: 22843840 Will the Initiator of Fatty Acid Synthesis in Pseudomonas Aeruginosa Please Stand Up? Journal of Bacteriology. Oct, 2012 | Pubmed ID: 22821980 Acyl-sulfamates Target the Essential Glycerol-phosphate Acyltransferase (PlsY) in Gram-positive Bacteria Bioorganic & Medicinal Chemistry. Aug, 2012 | Pubmed ID: 22795901 Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22442146 Atg8 Transfer from Atg7 to Atg3: a Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway Molecular Cell. Nov, 2011 | Pubmed ID: 22055190 Metabolic Basis for the Differential Susceptibility of Gram-positive Pathogens to Fatty Acid Synthesis Inhibitors Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21876172 Is Bacterial Fatty Acid Synthesis a Valid Target for Antibacterial Drug Discovery? Current Opinion in Microbiology. Oct, 2011 | Pubmed ID: 21862391 A σW-dependent Stress Response in Bacillus Subtilis That Reduces Membrane Fluidity Molecular Microbiology. Jul, 2011 | Pubmed ID: 21542858 A Rainbow Coalition of Lipid Transcriptional Regulators Molecular Microbiology. Oct, 2010 | Pubmed ID: 20941840 Modulation of Pantothenate Kinase 3 Activity by Small Molecules That Interact with the Substrate/allosteric Regulatory Domain Chemistry & Biology. Aug, 2010 | Pubmed ID: 20797618 Structural Basis for the Transcriptional Regulation of Membrane Lipid Homeostasis Nature Structural & Molecular Biology. Aug, 2010 | Pubmed ID: 20639888 Pantothenate Kinase 1 is Required to Support the Metabolic Transition from the Fed to the Fasted State PloS One. Jun, 2010 | Pubmed ID: 20559429 DesT Coordinates the Expression of Anaerobic and Aerobic Pathways for Unsaturated Fatty Acid Biosynthesis in Pseudomonas Aeruginosa Journal of Bacteriology. Jan, 2010 | Pubmed ID: 19880602 FabH Selectivity for Anteiso Branched-chain Fatty Acid Precursors in Low-temperature Adaptation in Listeria Monocytogenes FEMS Microbiology Letters. Dec, 2009 | Pubmed ID: 19863661 Transcriptional Regulation of Membrane Lipid Homeostasis in Escherichia Coli The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19854834 Opening a New Path to Lipoic Acid Journal of Bacteriology. Nov, 2009 | Pubmed ID: 19734307 Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19666474 Acyl-Acyl Carrier Protein Regulates Transcription of Fatty Acid Biosynthetic Genes Via the FabT Repressor in Streptococcus Pneumoniae The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19376778 Structural Modification of Acyl Carrier Protein by Butyryl Group Protein Science : a Publication of the Protein Society. Jan, 2009 | Pubmed ID: 19177367 Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19112175 Transcriptional Regulation in Bacterial Membrane Lipid Synthesis Journal of Lipid Research. Apr, 2009 | Pubmed ID: 18941141 Novel Acyl Phosphate Mimics That Target PlsY, an Essential Acyltransferase in Gram-positive Bacteria ChemMedChem. Dec, 2008 | Pubmed ID: 19016283 PqsD is Responsible for the Synthesis of 2,4-dihydroxyquinoline, an Extracellular Metabolite Produced by Pseudomonas Aeruginosa The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18728009 Analysis of the Staphylococcus Aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases Structure (London, England : 1993). Jul, 2008 | Pubmed ID: 18611377 Thematic Review Series: Glycerolipids. Acyltransferases in Bacterial Glycerophospholipid Synthesis Journal of Lipid Research. Sep, 2008 | Pubmed ID: 18369234 RhlA Converts Beta-hydroxyacyl-acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the Beta-hydroxydecanoyl-beta-hydroxydecanoate Component of Rhamnolipids in Pseudomonas Aeruginosa Journal of Bacteriology. May, 2008 | Pubmed ID: 18326581 Membrane Lipid Homeostasis in Bacteria Nature Reviews. Microbiology. Mar, 2008 | Pubmed ID: 18264115 A Pseudomonas Aeruginosa Transcription Factor That Senses Fatty Acid Structure Molecular Microbiology. Nov, 2007 | Pubmed ID: 17877713 Localization and Regulation of Mouse Pantothenate Kinase 2 FEBS Letters. Oct, 2007 | Pubmed ID: 17825826 Coupling of Fatty Acid and Phospholipid Synthesis in Bacillus Subtilis Journal of Bacteriology. Aug, 2007 | Pubmed ID: 17557823 Identification of a Soluble Diacylglycerol Kinase Required for Lipoteichoic Acid Production in Bacillus Subtilis The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17535816 Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia Coli L-asparaginase I Journal of Molecular Biology. Jun, 2007 | Pubmed ID: 17451745 Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis Chemistry & Biology. Mar, 2007 | Pubmed ID: 17379144 Topology and Active Site of PlsY: the Bacterial Acylphosphate:glycerol-3-phosphate Acyltransferase The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17308305 Activation of Human Mitochondrial Pantothenate Kinase 2 by Palmitoylcarnitine Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17242360 Acyl-phosphates Initiate Membrane Phospholipid Synthesis in Gram-positive Pathogens Molecular Cell. Sep, 2006 | Pubmed ID: 16949372 Placental Thrombosis and Spontaneous Fetal Death in Mice Deficient in Ethanolamine Kinase 2 The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16861741 Inhibiting Bacterial Fatty Acid Synthesis The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16648134 Structure of RhlG, an Essential Beta-ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas Aeruginosa The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16624803 Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus Pneumoniae The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16618705 Two Aerobic Pathways for the Formation of Unsaturated Fatty Acids in Pseudomonas Aeruginosa Molecular Microbiology. Apr, 2006 | Pubmed ID: 16573679 Structure-activity Relationships at the 5-position of Thiolactomycin: an Intact (5R)-isoprene Unit is Required for Activity Against the Condensing Enzymes from Mycobacterium Tuberculosis and Escherichia Coli Journal of Medicinal Chemistry. Jan, 2006 | Pubmed ID: 16392800 Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16272150 Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16040613 Coenzyme A: Back in Action Progress in Lipid Research. Mar-May, 2005 | Pubmed ID: 15893380 A Pantothenate Kinase from Staphylococcus Aureus Refractory to Feedback Regulation by Coenzyme A The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15548531 The Reductase Steps of the Type II Fatty Acid Synthase As Antimicrobial Targets Lipids. Nov, 2004 | Pubmed ID: 15726819 Acyl Carrier Protein is a Cellular Target for the Antibacterial Action of the Pantothenamide Class of Pantothenate Antimetabolites The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15459190 Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling Antimicrobial Agents and Chemotherapy. Aug, 2004 | Pubmed ID: 15273089 The Structure of the Pantothenate Kinase.ADP.pantothenate Ternary Complex Reveals the Relationship Between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15136582 Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols As Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15133034 Product Diversity and Regulation of Type II Fatty Acid Synthases Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Feb, 2004 | Pubmed ID: 15052334 Fatty Acid Biosynthesis As a Target for Novel Antibacterials Current Opinion in Investigational Drugs (London, England : 2000). Feb, 2004 | Pubmed ID: 15043388 Cofactor-induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG Structure (London, England : 1993). Mar, 2004 | Pubmed ID: 15016358 Key Residues Responsible for Acyl Carrier Protein and Beta-ketoacyl-acyl Carrier Protein Reductase (FabG) Interaction The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14527946 The 1.3-Angstrom-resolution Crystal Structure of Beta-ketoacyl-acyl Carrier Protein Synthase II from Streptococcus Pneumoniae Journal of Bacteriology. Jul, 2003 | Pubmed ID: 12837788 Crystal Structures of the Dab Homology Domains of Mouse Disabled 1 and 2 The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12826668 Role of Feedback Regulation of Pantothenate Kinase (CoaA) in Control of Coenzyme A Levels in Escherichia Coli Journal of Bacteriology. Jun, 2003 | Pubmed ID: 12754240 The Application of Computational Methods to Explore the Diversity and Structure of Bacterial Fatty Acid Synthase Journal of Lipid Research. Jan, 2003 | Pubmed ID: 12518017 Characterization of Streptococcus Pneumoniae Enoyl-(acyl-carrier Protein) Reductase (FabK) The Biochemical Journal. Mar, 2003 | Pubmed ID: 12487627 The Claisen Condensation in Biology Natural Product Reports. Oct, 2002 | Pubmed ID: 12430724 A New Mechanism for Anaerobic Unsaturated Fatty Acid Formation in Streptococcus Pneumoniae The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12237320 The Murine Pantothenate Kinase (Pank1) Gene Encodes Two Differentially Regulated Pantothenate Kinase Isozymes Gene. May, 2002 | Pubmed ID: 12095677 Forty Years of Bacterial Fatty Acid Synthesis Biochemical and Biophysical Research Communications. Apr, 2002 | Pubmed ID: 11969206 A Missense Mutation in the FabB (beta-ketoacyl-acyl Carrier Protein Synthase I) Gene Confers Tiolactomycin Resistance to Escherichia Coli Antimicrobial Agents and Chemotherapy. May, 2002 | Pubmed ID: 11959552 Dual Roles for the Dab2 Adaptor Protein in Embryonic Development and Kidney Transport The EMBO Journal. Apr, 2002 | Pubmed ID: 11927540 The FabR (YijC) Transcription Factor Regulates Unsaturated Fatty Acid Biosynthesis in Escherichia Coli The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11859088 The Solution Structure of Acyl Carrier Protein from Mycobacterium Tuberculosis The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11825906 Disabled-2 is Transcriptionally Regulated by ICSBP and Augments Macrophage Spreading and Adhesion The EMBO Journal. Feb, 2002 | Pubmed ID: 11823414 Structure and Mechanism of CTP:phosphocholine Cytidylyltransferase (LicC) from Streptococcus Pneumoniae The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11706035 The LicC Gene of Streptococcus Pneumoniae Encodes a CTP:phosphocholine Cytidylyltransferase Journal of Bacteriology. Aug, 2001 | Pubmed ID: 11466299 Response of Bacillus Subtilis to Cerulenin and Acquisition of Resistance Journal of Bacteriology. May, 2001 | Pubmed ID: 11325930 Beta-ketoacyl-acyl Carrier Protein Synthase III (FabH) is a Determining Factor in Branched-chain Fatty Acid Biosynthesis Journal of Bacteriology. Jan, 2000 | Pubmed ID: 10629181 A Missense Mutation Accounts for the Defect in the Glycerol-3-phosphate Acyltransferase Expressed in the PlsB26 Mutant Journal of Bacteriology. Mar, 1999 | Pubmed ID: 10074094 A Conserved Histidine is Essential for Glycerolipid Acyltransferase Catalysis Journal of Bacteriology. Mar, 1998 | Pubmed ID: 9515909 Roles of the FabA and FabZ Beta-hydroxyacyl-acyl Carrier Protein Dehydratases in Escherichia Coli Fatty Acid Biosynthesis The Journal of Biological Chemistry. Nov, 1996 | Pubmed ID: 8910376 細胞および組織におけるコエンザイムAの定量 Matthew W. Frank1, Chitra Subramanian1, Charles O. Rock1, Suzanne Jackowski1 1Department of Infectious Diseases, St. Jude Children's Research Hospital JoVE 60182 Biochemistry
細胞および組織におけるコエンザイムAの定量 Matthew W. Frank1, Chitra Subramanian1, Charles O. Rock1, Suzanne Jackowski1 1Department of Infectious Diseases, St. Jude Children's Research Hospital JoVE 60182 Biochemistry