Chris P. Reutelingsperger Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Biography Publications Institution JoVE Articles Chris P. Reutelingsperger has not added a biography. If you are Chris P. Reutelingsperger and would like to personalize this page please email our Author Liaison for assistance. Publications Prenatal Administration of Multipotent Adult Progenitor Cells Modulates the Systemic and Cerebral Immune Response in an Ovine Model of Chorioamnionitis Brain, Behavior, & Immunity - Health. Aug, 2022 | Pubmed ID: 35647567 Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells International Journal of Molecular Sciences. Feb, 2022 | Pubmed ID: 35269792 Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with Von Willebrand Factor-Binding, Affecting Platelet Aggregation Under Shear International Journal of Molecular Sciences. Feb, 2022 | Pubmed ID: 35216161 Development of IgG, IgM, and IgA Autoantibodies Against Angiotensin Converting Enzyme 2 in Patients with COVID-19 The Journal of Applied Laboratory Medicine. 01, 2022 | Pubmed ID: 34213568 Deficiency of Myeloid PHD Proteins Aggravates Atherogenesis Via Macrophage Apoptosis and Paracrine Fibrotic Signalling Cardiovascular Research. 03, 2022 | Pubmed ID: 33913468 Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity Frontiers in Medicine. 2021 | Pubmed ID: 35004784 Conformational Plasticity of ADAMTS13 in Hemostasis and Autoimmunity The Journal of Biological Chemistry. 10, 2021 | Pubmed ID: 34461090 Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity Cells. 08, 2021 | Pubmed ID: 34440866 The Role of Extracellular Vesicles During CNS Development Progress in Neurobiology. 10, 2021 | Pubmed ID: 34314775 Functional and Genetic Landscape of Complement Dysregulation Along the Spectrum of Thrombotic Microangiopathy and Its Potential Implications on Clinical Outcomes Kidney International Reports. Apr, 2021 | Pubmed ID: 33912760 PAD4 Takes Charge During Neutrophil Activation: Impact of PAD4 Mediated NET Formation on Immune-mediated Disease Journal of Thrombosis and Haemostasis : JTH. 07, 2021 | Pubmed ID: 33773016 Off-target Effects of Oral Anticoagulants - Vascular Effects of Vitamin K Antagonist and Non-vitamin K Antagonist Oral Anticoagulant Dabigatran Etexilate Journal of Thrombosis and Haemostasis : JTH. 05, 2021 | Pubmed ID: 33687782 Autocitrullination of PAD4 Does Not Alter Its Enzymatic Activity: In Vitro and in Silico Studies The International Journal of Biochemistry & Cell Biology. 05, 2021 | Pubmed ID: 33529715 Extracellular Vesicles in CNS Developmental Disorders International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33322331 Urinary Soluble CD163 and Disease Activity in Biopsy-Proven ANCA-Associated Glomerulonephritis Clinical Journal of the American Society of Nephrology : CJASN. 12, 2020 | Pubmed ID: 33203735 Neutrophils and Contact Activation of Coagulation As Potential Drivers of COVID-19 Circulation. 11, 2020 | Pubmed ID: 32946302 The Anticoagulant and Nonanticoagulant Properties of Heparin Thrombosis and Haemostasis. Oct, 2020 | Pubmed ID: 32820487 More About Complement in the Antiphospholipid Syndrome Blood. 09, 2020 | Pubmed ID: 32462204 The Natural Course of Pregnancies in Women with Primary Atypical Haemolytic Uraemic Syndrome and Asymptomatic Relatives British Journal of Haematology. 08, 2020 | Pubmed ID: 32342491 Annexin A1 Drives Macrophage Skewing to Accelerate Muscle Regeneration Through AMPK Activation The Journal of Clinical Investigation. 03, 2020 | Pubmed ID: 32015229 Diagnostic and Risk Factors for Complement Defects in Hypertensive Emergency and Thrombotic Microangiopathy Hypertension (Dallas, Tex. : 1979). 02, 2020 | Pubmed ID: 31865800 Variability of Microcirculatory Measurements in Critically Ill Patients Shock (Augusta, Ga.). 07, 2020 | Pubmed ID: 31743299 Low Human and Murine Mcl-1 Expression Leads to a Pro-apoptotic Plaque Phenotype Enriched in Giant-cells Scientific Reports. 10, 2019 | Pubmed ID: 31601924 Proteomic Analysis of Neutrophils in ANCA-associated Vasculitis Reveals a Dysregulation in Proteinase 3-associated Proteins Such As Annexin-A1 Involved in Apoptotic Cell Clearance Kidney International. 08, 2019 | Pubmed ID: 31142442 Annexin A1 As Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy Journal of Clinical Medicine. Jan, 2019 | Pubmed ID: 30682787 A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers Nutrients. Jun, 2018 | Pubmed ID: 29891757 C5b9 Formation on Endothelial Cells Reflects Complement Defects Among Patients with Renal Thrombotic Microangiopathy and Severe Hypertension Journal of the American Society of Nephrology : JASN. 08, 2018 | Pubmed ID: 29858281 Ucma/GRP Inhibits Phosphate-induced Vascular Smooth Muscle Cell Calcification Via SMAD-dependent BMP Signalling Scientific Reports. 03, 2018 | Pubmed ID: 29563538 Insights into 3D Structure of ADAMTS13: A Stepping Stone Towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura Thrombosis and Haemostasis. 01, 2018 | Pubmed ID: 29304523 Coronary Artery Calcification: A Janus-Faced Biomarker? JACC. Cardiovascular Imaging. 09, 2018 | Pubmed ID: 28734912 Patients with Hypertension-associated Thrombotic microangiopathy May Present With complement Abnormalities Kidney International. 06, 2017 | Pubmed ID: 28187980 Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys Transplantation. 04, 2017 | Pubmed ID: 27906828 Extracellular Histone H3 Levels Are Inversely Correlated with Antithrombin Levels and Platelet Counts and Are Associated with Mortality in Sepsis Patients Thrombosis Research. Sep, 2015 | Pubmed ID: 26232351 Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet PloS One. 2015 | Pubmed ID: 26090792 Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion Circulation Research. Apr, 2015 | Pubmed ID: 25711438 AnxA5 Reduces Plaque Inflammation of Advanced Atherosclerotic Lesions in ApoE(-/-) Mice Journal of Cellular and Molecular Medicine. Oct, 2014 | Pubmed ID: 25214012 Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis PloS One. 2014 | Pubmed ID: 25032959 A Dual-labeled Annexin A5 is Not Suited for SPECT Imaging of Brain Cell Death in Experimental Murine Stroke Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Sep, 2014 | Pubmed ID: 24984896 Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-targeting Function to Tumor Uptake PloS One. 2014 | Pubmed ID: 24801051 The Realm of Vitamin K Dependent Proteins: Shifting from Coagulation Toward Calcification Molecular Nutrition & Food Research. Aug, 2014 | Pubmed ID: 24668744 Nonanticoagulant Heparin Prevents Histone-mediated Cytotoxicity in Vitro and Improves Survival in Sepsis Blood. Feb, 2014 | Pubmed ID: 24264231 99mTc-HYNIC-Annexin A5 in Oncology: Evaluating Efficacy of Anti-Cancer Therapies Cancers. May, 2013 | Pubmed ID: 24216991 Mechanisms of Arterial Remodeling: Lessons from Genetic Diseases Frontiers in Genetics. 2012 | Pubmed ID: 23248645 Molecular Imaging to Identify the Vulnerable Plaque--from Basic Research to Clinical Practice Molecular Imaging and Biology. Oct, 2012 | Pubmed ID: 22983911 Vitamin K-antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype PloS One. 2012 | Pubmed ID: 22952653 Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 21078669 Annexin A5-functionalized Bimodal Nanoparticles for MRI and Fluorescence Imaging of Atherosclerotic Plaques Bioconjugate Chemistry. Oct, 2010 | Pubmed ID: 20804153 Transfection Efficiency of Lipoplexes for Site-directed Delivery Journal of Liposome Research. Sep, 2010 | Pubmed ID: 19947825 Nanoparticles for Optical Molecular Imaging of Atherosclerosis Small (Weinheim an Der Bergstrasse, Germany). Mar, 2009 | Pubmed ID: 19226595 Noninvasive Imaging of Angiotensin Receptors After Myocardial Infarction JACC. Cardiovascular Imaging. May, 2008 | Pubmed ID: 19356449 Key Role of Platelet Procoagulant Activity in Tissue Factor-and Collagen-dependent Thrombus Formation in Arterioles and Venules in Vivo Differential Sensitivity to Thrombin Inhibition Microcirculation (New York, N.Y. : 1994). May, 2008 | Pubmed ID: 18464157 Factor Xa-driven Thrombin Generation in Plasma: Dependency on the Aminophospholipid Density of Membranes and Inhibition by Phospholipid-binding Proteins Thrombosis and Haemostasis. Nov, 2007 | Pubmed ID: 18000611 Imaging Apoptosis for Detecting Plaque Instability: Rendering Death a Brighter Facade Current Opinion in Biotechnology. Feb, 2007 | Pubmed ID: 17275277 Past, Present, and Future of Annexin A5: from Protein Discovery to Clinical Applications Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2005 | Pubmed ID: 16330568 Novel Conformation-specific Antibodies Against Matrix Gamma-carboxyglutamic Acid (Gla) Protein: Undercarboxylated Matrix Gla Protein As Marker for Vascular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2005 | Pubmed ID: 15961706 A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry