Christopher B. Little Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital University of Sydney Biography Publications Institution JoVE Articles Christopher B. Little has not added a biography. If you are Christopher B. Little and would like to personalize this page please email our Author Liaison for assistance. Publications The Relationship Between Synovial Inflammation, Structural Pathology, and Pain in Post-traumatic Osteoarthritis: Differential Effect of Stem Cell and Hyaluronan Treatment Arthritis Research & Therapy. 02, 2020 | Pubmed ID: 32059749 Stem Cell-directed Therapies for Osteoarthritis: The Promise and the Practice Stem Cells (Dayton, Ohio). Apr, 2020 | Pubmed ID: 31837053 Assessment for Varicella Zoster Virus in Patients Newly Suspected of Having Giant Cell Arteritis Rheumatology (Oxford, England). Nov, 2019 | Pubmed ID: 31776576 Functionally Distinct Tendons Have Different Biomechanical, Biochemical and Histological Responses to in Vitro Unloading Journal of Biomechanics. Oct, 2019 | Pubmed ID: 31466714 Adding Insult to Injury: Synergistic Effect of Combining Risk-factors in Models of Post-traumatic Osteoarthritis Osteoarthritis and Cartilage. 12, 2019 | Pubmed ID: 31276817 Disruption of Glucocorticoid Signalling in Osteoblasts Attenuates Age-related Surgically Induced Osteoarthritis Osteoarthritis and Cartilage. 10, 2019 | Pubmed ID: 31176016 Effects of Tendon Injury on Uninjured Regional Tendons in the Distal Limb: An In-vivo Study Using an Ovine Tendinopathy Model PloS One. 2019 | Pubmed ID: 31013317 Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis Nanomaterials (Basel, Switzerland). Feb, 2019 | Pubmed ID: 30769853 Developing Strategic Priorities in Osteoarthritis Research: Proceedings and Recommendations Arising from the 2017 Australian Osteoarthritis Summit BMC Musculoskeletal Disorders. Feb, 2019 | Pubmed ID: 30760253 Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs International Journal of Molecular Sciences. Jan, 2019 | Pubmed ID: 30700002 Elevated Hypertrophy, Growth Plate Maturation, Glycosaminoglycan Deposition, and Exostosis Formation in the Exon 3 Null Mouse Intervertebral Disc The Biochemical Journal. 01, 2019 | Pubmed ID: 30563944 Efficacy of Administered Mesenchymal Stem Cells in the Initiation and Co-ordination of Repair Processes by Resident Disc Cells in an Ovine (Ovis Aries) Large Destabilizing Lesion Model of Experimental Disc Degeneration JOR Spine. Dec, 2018 | Pubmed ID: 31463452 Achilles and Tail Tendons of Perlecan Exon 3 Null Heparan Sulphate Deficient Mice Display Surprising Improvement in Tendon Tensile Properties and Altered Collagen Fibril Organisation Compared to C57BL/6 Wild Type Mice PeerJ. 2018 | Pubmed ID: 30042881 Identification of TGFβ-related Genes Regulated in Murine Osteoarthritis and Chondrocyte Hypertrophy by Comparison of Multiple Microarray Datasets Bone. 11, 2018 | Pubmed ID: 30010080 Macrophage Polarization Contributes to Local Inflammation and Structural Change in the Multifidus Muscle After Intervertebral Disc Injury European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 08, 2018 | Pubmed ID: 29948327 Preclinical Randomized Controlled Trial of Bilateral Discectomy Versus Bilateral Discopexy in Black Merino Sheep Temporomandibular Joint: TEMPOJIMS - Phase 1- Histologic, Imaging and Body Weight Results Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery. Apr, 2018 | Pubmed ID: 29500103 The Role of Fat and Inflammation in the Pathogenesis and Management of Osteoarthritis Rheumatology (Oxford, England). 05, 2018 | Pubmed ID: 29444323 Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc? Stem Cells and Development. 02, 2018 | Pubmed ID: 29241405 Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End-Stage Human Disease Arthritis & Rheumatology (Hoboken, N.J.). 03, 2018 | Pubmed ID: 29145712 Biomarkers for Equine Joint Injury and Osteoarthritis Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 03, 2018 | Pubmed ID: 28921609 Hyaluronan Oligosaccharides Stimulate Matrix Metalloproteinase and Anabolic Gene Expression in Vitro by Intervertebral Disc Cells and Annular Repair in Vivo Journal of Tissue Engineering and Regenerative Medicine. 01, 2018 | Pubmed ID: 27689852 Comprehensive Expression Analysis of MicroRNAs and MRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis Scientific Reports. 12, 2017 | Pubmed ID: 29255152 A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration International Journal of Molecular Sciences. May, 2017 | Pubmed ID: 28498326 Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS) JMIR Research Protocols. Mar, 2017 | Pubmed ID: 28254733 The Biology of Meniscal Pathology in Osteoarthritis and Its Contribution to Joint Disease: Beyond Simple Mechanics Connective Tissue Research. May - Jul, 2017 | Pubmed ID: 28121190 Considerations for the Design and Execution of Protocols for Animal Research and Treatment to Improve Reproducibility and Standardization: "DEPART Well-prepared and ARRIVE Safely" Osteoarthritis and Cartilage. 03, 2017 | Pubmed ID: 27816577 Utility of Circulating Serum MiRNAs As Biomarkers of Early Cartilage Degeneration in Animal Models of Post-traumatic Osteoarthritis and Inflammatory Arthritis Osteoarthritis and Cartilage. 03, 2017 | Pubmed ID: 27621213 Joint Loads Resulting in ACL Rupture: Effects of Age, Sex, and Body Mass on Injury Load and Mode of Failure in a Mouse Model Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 08, 2017 | Pubmed ID: 27601010 Using Mouse Models to Investigate the Pathophysiology, Treatment, and Prevention of Post-traumatic Osteoarthritis Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 03, 2017 | Pubmed ID: 27312470 Use of FGF-2 and FGF-18 to Direct Bone Marrow Stromal Stem Cells to Chondrogenic and Osteogenic Lineages Future Science OA. Dec, 2016 | Pubmed ID: 28116125 Interleukin-1α Induces Focal Degradation of Biglycan and Tissue Degeneration in an In-vitro Ovine Meniscal Model Experimental and Molecular Pathology. Oct, 2016 | Pubmed ID: 27615609 Chondroitin Sulphate Glycosaminoglycans Contribute to Widespread Inferior Biomechanics in Tendon After Focal Injury Journal of Biomechanics. 09, 2016 | Pubmed ID: 27316761 Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but Not Cytokine and Muscle Fiber Changes Spine. Aug, 2016 | Pubmed ID: 27135642 The CS Sulfation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow Stem Cells and Development. 06, 2016 | Pubmed ID: 27068010 The Great Debate: Should Osteoarthritis Research Focus on "Mice" or "Men"? Osteoarthritis and Cartilage. Jan, 2016 | Pubmed ID: 26707987 Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis Arthritis & Rheumatology (Hoboken, N.J.). Apr, 2016 | Pubmed ID: 26636652 The Role of Proteoglycans in the Nanoindentation Creep Behavior of Human Dentin Journal of the Mechanical Behavior of Biomedical Materials. Mar, 2015 | Pubmed ID: 26600409 On the Predictive Utility of Animal Models of Osteoarthritis Arthritis Research & Therapy. Sep, 2015 | Pubmed ID: 26364707 Focal Experimental Injury Leads to Widespread Gene Expression and Histologic Changes in Equine Flexor Tendons PloS One. 2015 | Pubmed ID: 25837713 Depletion of Protease-activated Receptor 2 but Not Protease-activated Receptor 1 May Confer Protection Against Osteoarthritis in Mice Through Extracartilaginous Mechanisms Arthritis & Rheumatology (Hoboken, N.J.). Dec, 2014 | Pubmed ID: 25200274 Treatment of Experimentally Induced Osteoarthritis in Horses Using an Intravenous Combination of Sodium Pentosan Polysulfate, N-acetyl Glucosamine, and Sodium Hyaluronan Veterinary Surgery : VS. Jul, 2014 | Pubmed ID: 24819506 Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes Arthritis & Rheumatology (Hoboken, N.J.). Jun, 2014 | Pubmed ID: 24574263 Endothelial Protein C Receptor-associated Invasiveness of Rheumatoid Synovial Fibroblasts is Likely Driven by Group V Secretory Phospholipase A2 Arthritis Research & Therapy. Feb, 2014 | Pubmed ID: 24495480 A Commentary on Modelling Osteoarthritis Pain in Small Animals Osteoarthritis and Cartilage. Sep, 2013 | Pubmed ID: 23973146 A Hexadecylamide Derivative of Hyaluronan (HYMOVIS®) Has Superior Beneficial Effects on Human Osteoarthritic Chondrocytes and Synoviocytes Than Unmodified Hyaluronan Journal of Inflammation (London, England). 2013 | Pubmed ID: 23889808 The Ovine Newborn and Human Foetal Intervertebral Disc Contain Perlecan and Aggrecan Variably Substituted with Native 7D4 CS Sulphation Motif: Spatiotemporal Immunolocalisation and Co-distribution with Notch-1 in the Human Foetal Disc Glycoconjugate Journal. Oct, 2013 | Pubmed ID: 23756834 Post-traumatic Osteoarthritis: from Mouse Models to Clinical Trials Nature Reviews. Rheumatology. Aug, 2013 | Pubmed ID: 23689231 Comparative Immunolocalisation of Perlecan, Heparan Sulphate, Fibroblast Growth Factor-18, and Fibroblast Growth Factor Receptor-3 and Their Prospective Roles in Chondrogenic and Osteogenic Development of the Human Foetal Spine European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Aug, 2013 | Pubmed ID: 23397188 Altered Stress Induced by Partial Transection of the Infraspinatus Tendon Leads to Perlecan (HSPG2) Accumulation in an Ovine Model of Tendinopathy Tissue & Cell. Feb, 2013 | Pubmed ID: 23245384 The Interaction of Canonical Bone Morphogenetic Protein- and Wnt-signaling Pathways May Play an Important Role in Regulating Cartilage Degradation in Osteoarthritis Arthritis Research & Therapy. Jun, 2012 | Pubmed ID: 22676306 Chondroitin Sulphate and Heparan Sulphate Sulphation Motifs and Their Proteoglycans Are Involved in Articular Cartilage Formation During Human Foetal Knee Joint Development Histochemistry and Cell Biology. Sep, 2012 | Pubmed ID: 22617995 What Constitutes an "animal Model of Osteoarthritis"--the Need for Consensus? Osteoarthritis and Cartilage. Apr, 2012 | Pubmed ID: 22321719 Mechanical Destabilization Induced by Controlled Annular Incision of the Intervertebral Disc Dysregulates Metalloproteinase Expression and Induces Disc Degeneration Spine. Jan, 2012 | Pubmed ID: 22179320 Cartilage Intermediate Layer Protein 2 (CILP-2) is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21880736 The OARSI Histopathology Initiative - Recommendations for Histological Assessments of Osteoarthritis in Sheep and Goats Osteoarthritis and Cartilage. Oct, 2010 | Pubmed ID: 20864026 Anti-IgD Antibody Attenuates Collagen-induced Arthritis by Selectively Depleting Mature B-cells and Promoting Immune Tolerance Journal of Autoimmunity. Aug, 2010 | Pubmed ID: 20456921 Immunolocalization of Lymphatic Vessels in Human Fetal Knee Joint Tissues Connective Tissue Research. Aug, 2010 | Pubmed ID: 20334573 Is Cartilage Matrix Breakdown an Appropriate Therapeutic Target in Osteoarthritis--insights from Studies of Aggrecan and Collagen Proteolysis? Current Drug Targets. May, 2010 | Pubmed ID: 20199393 S100A8 and S100A9 in Experimental Osteoarthritis Arthritis Research & Therapy. 2010 | Pubmed ID: 20105291 Topographical Variation in the Distributions of Versican, Aggrecan and Perlecan in the Foetal Human Spine Reflects Their Diverse Functional Roles in Spinal Development Histochemistry and Cell Biology. Nov, 2009 | Pubmed ID: 19669783 Activation of Cartilage Matrix Metalloproteinases by Activated Protein C Arthritis and Rheumatism. Mar, 2009 | Pubmed ID: 19248107 Activated Protein C Mediates a Healing Phenotype in Cultured Tenocytes Journal of Cellular and Molecular Medicine. Apr, 2009 | Pubmed ID: 18466356 Fragmentation of Decorin, Biglycan, Lumican and Keratocan is Elevated in Degenerate Human Meniscus, Knee and Hip Articular Cartilages Compared with Age-matched Macroscopically Normal and Control Tissues Arthritis Research & Therapy. 2008 | Pubmed ID: 18620607 Recent Advances in Annular Pathobiology Provide Insights into Rim-lesion Mediated Intervertebral Disc Degeneration and Potential New Approaches to Annular Repair Strategies European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Sep, 2008 | Pubmed ID: 18584218 Perlecan, the "jack of All Trades" Proteoglycan of Cartilaginous Weight-bearing Connective Tissues BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. May, 2008 | Pubmed ID: 18404701 Aggrecan, Versican and Type VI Collagen Are Components of Annular Translamellar Crossbridges in the Intervertebral Disc European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Feb, 2008 | Pubmed ID: 17972112 Biglycan and Fibromodulin Fragmentation Correlates with Temporal and Spatial Annular Remodelling in Experimentally Injured Ovine Intervertebral Discs European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Dec, 2007 | Pubmed ID: 17899219 Blocking Aggrecanase Cleavage in the Aggrecan Interglobular Domain Abrogates Cartilage Erosion and Promotes Cartilage Repair The Journal of Clinical Investigation. Jun, 2007 | Pubmed ID: 17510707 Dynamic Biomechanics Correlate with Histopathology in Human Tibial Cartilage: a Preliminary Study Clinical Orthopaedics and Related Research. Sep, 2007 | Pubmed ID: 17496559 Proteoglycan 4 Downregulation in a Sheep Meniscectomy Model of Early Osteoarthritis Arthritis Research & Therapy. 2006 | Pubmed ID: 16469119 Regional Assessment of Articular Cartilage Gene Expression and Small Proteoglycan Metabolism in an Animal Model of Osteoarthritis Arthritis Research & Therapy. 2005 | Pubmed ID: 15987487 Spatial and Temporal Localization of Transforming Growth Factor-beta, Fibroblast Growth Factor-2, and Osteonectin, and Identification of Cells Expressing Alpha-smooth Muscle Actin in the Injured Anulus Fibrosus: Implications for Extracellular Matrix Repair Spine. Aug, 2002 | Pubmed ID: 12195068 骨关节炎模型中骨髓、骨髓、淋巴结和合成组织内免疫细胞子集的流动细胞测量分析 Patrick Haubruck1,2, Aimee C. Colbath1,3, Yolanda Liu1, Shihani Stoner1, Cindy Shu1, Christopher B. Little1 1Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, 2HTRG - Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, 3Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University JoVE 61008 Medicine
骨关节炎模型中骨髓、骨髓、淋巴结和合成组织内免疫细胞子集的流动细胞测量分析 Patrick Haubruck1,2, Aimee C. Colbath1,3, Yolanda Liu1, Shihani Stoner1, Cindy Shu1, Christopher B. Little1 1Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, 2HTRG - Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, 3Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University JoVE 61008 Medicine
