Christopher C. W. Hughes Molecular Biology and Biochemistry University of California, Irvine Biography Publications Institution JoVE Articles Christopher C. W. Hughes has not added a biography. If you are Christopher C. W. Hughes and would like to personalize this page please email our Author Liaison for assistance. Publications A Human Vascularized Microtumor Model of Patient-derived Colorectal Cancer Recapitulates Clinical Disease Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2023 | Pubmed ID: 36481562 Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks Scientific Reports. Nov, 2022 | Pubmed ID: 36443378 Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review The Oncologist. Mar, 2022 | Pubmed ID: 35274719 Correction: The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34472547 The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34396383 An in Vitro Vascularized Micro-tumor Model of Human Colorectal Cancer Recapitulates in Vivo Responses to Standard-of-care Therapy Lab on a Chip. Apr, 2021 | Pubmed ID: 33605955 Slug Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis Nature Communications. Oct, 2020 | Pubmed ID: 33106502 Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions Stem Cell Reports. Mar, 2019 | Pubmed ID: 30745035 Pazopanib May Reduce Bleeding in Hereditary Hemorrhagic Telangiectasia Angiogenesis. Feb, 2019 | Pubmed ID: 30191360 Executive Summary of the 12th HHT International Scientific Conference Angiogenesis. Feb, 2018 | Pubmed ID: 29147802 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28634954 A Vascularized and Perfused Organ-on-a-chip Platform for Large-scale Drug Screening Applications Lab on a Chip. Jan, 2017 | Pubmed ID: 28092382 Recapitulating the Human Tumor Microenvironment: Colon Tumor-derived Extracellular Matrix Promotes Angiogenesis and Tumor Cell Growth Biomaterials. Feb, 2017 | Pubmed ID: 27914984 MTORC2 Mediates CXCL12-induced Angiogenesis Angiogenesis. Jul, 2016 | Pubmed ID: 27106789 Engineering Anastomosis Between Living Capillary Networks and Endothelial Cell-lined Microfluidic Channels Lab on a Chip. Jan, 2016 | Pubmed ID: 26616908 Executive Summary of the 11th HHT International Scientific Conference Angiogenesis. Oct, 2015 | Pubmed ID: 26391603 A Role for Partial Endothelial-mesenchymal Transitions in Angiogenesis? Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015 | Pubmed ID: 25425619 Interferon-induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2014 | Pubmed ID: 24603679 Angiogenic Sprouting is Regulated by Endothelial Cell Expression of Slug Journal of Cell Science. May, 2014 | Pubmed ID: 24554431 Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell-derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2013 | Pubmed ID: 23288153 Macrophages and Angiogenesis: a Role for Wnt Signaling Vascular Cell. 2012 | Pubmed ID: 22938389 BMP9 Induces EphrinB2 Expression in Endothelial Cells Through an Alk1-BMPRII/ActRII-ID1/ID3-dependent Pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II Angiogenesis. Sep, 2012 | Pubmed ID: 22622516 Integration of the Beta-catenin-dependent Wnt Pathway with Integrin Signaling Through the Adaptor Molecule Grb2 PloS One. 2009 | Pubmed ID: 19924227 TNF Induction of Jagged-1 in Endothelial Cells is NFkappaB-dependent Gene. Apr, 2009 | Pubmed ID: 19393188 Prevascularization of a Fibrin-based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature Tissue Engineering. Part A. Jun, 2009 | Pubmed ID: 18976155 An Optimized Three-dimensional in Vitro Model for the Analysis of Angiogenesis Methods in Enzymology. 2008 | Pubmed ID: 18772011 Endothelial-stromal Interactions in Angiogenesis Current Opinion in Hematology. May, 2008 | Pubmed ID: 18391786 Wnt Signaling Induces Matrix Metalloproteinase Expression and Regulates T Cell Transmigration Immunity. Feb, 2007 | Pubmed ID: 17306568 Mesenchymal Stem Cells Enhance Angiogenesis in Mechanically Viable Prevascularized Tissues Via Early Matrix Metalloproteinase Upregulation Tissue Engineering. Oct, 2006 | Pubmed ID: 17518656 HESR1/CHF2 Suppresses VEGFR2 Transcription Independent of Binding to E-boxes Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16782059 Cell-autonomous Notch Signaling Regulates Endothelial Cell Branching and Proliferation During Vascular Tubulogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15774577 VEGF(121) and VEGF(165) Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor 2 in an in Vitro Angiogenesis Model Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2003 | Pubmed ID: 14691306 Notch Activation During Endothelial Cell Network Formation in Vitro Targets the Basic HLH Transcription Factor HESR-1 and Downregulates VEGFR-2/KDR Expression Microvascular Research. Nov, 2002 | Pubmed ID: 12453432 Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research
Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research