Claus Desler Department of Cellular and Molecular Medicine, Center for Healthy Aging University of Copenhagen Biography Publications Institution JoVE Articles Claus Desler has not added a biography. If you are Claus Desler and would like to personalize this page please email our Author Liaison for assistance. Publications Atorvastatin Impairs Liver Mitochondrial Function in Obese Göttingen Minipigs but Heart and Skeletal Muscle Are Not Affected Scientific Reports. 01, 2021 | Pubmed ID: 33500513 Bloom Syndrome DNA Helicase Deficiency is Associated with Oxidative Stress and Mitochondrial Network Changes Scientific Reports. 01, 2021 | Pubmed ID: 33495511 Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease IScience. Oct, 2020 | Pubmed ID: 33083725 Simvastatin Improves Mitochondrial Respiration in Peripheral Blood Cells Scientific Reports. 10, 2020 | Pubmed ID: 33046789 Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells Frontiers in Immunology. 2020 | Pubmed ID: 32849657 Mitochondrial Function in Gilles De La Tourette Syndrome Patients With and Without Intragenic Deletions Frontiers in Neurology. 2020 | Pubmed ID: 32265818 MERTK Acts As a Costimulatory Receptor on Human CD8 T Cells Cancer Immunology Research. Sep, 2019 | Pubmed ID: 31266785 From Powerhouse to Perpetrator-Mitochondria in Health and Disease Biology. May, 2019 | Pubmed ID: 31083572 Mitochondrial Oxidative Phosphorylation Capacity of Cryopreserved Cells Mitochondrion. 07, 2019 | Pubmed ID: 31051261 The Inhibitors of Soluble Adenylate Cyclase 2-OHE, KH7, and Bithionol Compromise Mitochondrial ATP Production by Distinct Mechanisms Biochemical Pharmacology. 09, 2018 | Pubmed ID: 29940175 Author Correction: Rev1 Contributes to Proper Mitochondrial Function Via the PARP-NAD-SIRT1-PGC1α Axis Scientific Reports. Mar, 2018 | Pubmed ID: 29511198 Initial Brain Aging: Heterogeneity of Mitochondrial Size is Associated with Decline in Complex I-linked Respiration in Cortex and Hippocampus Neurobiology of Aging. 01, 2018 | Pubmed ID: 29031832 The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease Current Medicinal Chemistry. 2018 | Pubmed ID: 28618998 Rev1 Contributes to Proper Mitochondrial Function Via the PARP-NAD-SIRT1-PGC1α Axis Scientific Reports. 10, 2017 | Pubmed ID: 28970491 Bacterial Infection Increases Risk of Carcinogenesis by Targeting Mitochondria Seminars in Cancer Biology. 12, 2017 | Pubmed ID: 28754330 Bioenergetic Changes During Differentiation of Human Embryonic Stem Cells Along the Hepatic Lineage Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 28265337 Disturbed Mitochondrial Function Restricts Glutamate Uptake in the Human Müller Glia Cell Line, MIO-M1 Mitochondrion. 09, 2017 | Pubmed ID: 28185966 A Novel Rrm3 Function in Restricting DNA Replication Via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function As an ATPase/Helicase in Facilitating Fork Progression PLoS Genetics. Dec, 2016 | Pubmed ID: 27923055 Oxidative Stress-Induced Dysfunction of Müller Cells During Starvation Investigative Ophthalmology & Visual Science. 05, 2016 | Pubmed ID: 27196320 Defective Mitochondrial Respiration, Altered DNTP Pools and Reduced AP Endonuclease 1 Activity in Peripheral Blood Mononuclear Cells of Alzheimer's Disease Patients Aging. Oct, 2015 | Pubmed ID: 26539816 Increased Deoxythymidine Triphosphate Levels is a Feature of Relative Cognitive Decline Mitochondrion. Nov, 2015 | Pubmed ID: 26408413 Increased Rrm2 Gene Dosage Reduces Fragile Site Breakage and Prolongs Survival of ATR Mutant Mice Genes & Development. Apr, 2015 | Pubmed ID: 25838540 Mitochondria in Health and Disease - 3rd Annual Conference of Society for Mitochondrial Research and Medicine - 19-20 December 2013 - Bengaluru, India Mitochondrion. Jan, 2015 | Pubmed ID: 25446394 Introducing the Hypothome: a Way to Integrate Predicted Proteins in Interactomes International Journal of Bioinformatics Research and Applications. 2014 | Pubmed ID: 25335568 Impact of Bacterial Infections on Aging and Cancer: Impairment of DNA Repair and Mitochondrial Function of Host Cells Experimental Gerontology. Aug, 2014 | Pubmed ID: 24704713 Overexpression of DNA Ligase III in Mitochondria Protects Cells Against Oxidative Stress and Improves Mitochondrial DNA Base Excision Repair DNA Repair. Apr, 2014 | Pubmed ID: 24674627 Relationships Between Human Vitality and Mitochondrial Respiratory Parameters, Reactive Oxygen Species Production and DNTP Levels in Peripheral Blood Mononuclear Cells Aging. Nov, 2013 | Pubmed ID: 24304678 Mitochondria in Biology and Medicine - 2012 Mitochondrion. May, 2013 | Pubmed ID: 23727386 Enterococcus Faecalis Infection Causes Inflammation, Intracellular Oxphos-independent ROS Production, and DNA Damage in Human Gastric Cancer Cells PloS One. 2013 | Pubmed ID: 23646188 Oxidative Damage to DNA by Diesel Exhaust Particle Exposure in Co-cultures of Human Lung Epithelial Cells and Macrophages Mutagenesis. Nov, 2012 | Pubmed ID: 22869610 Mitochondria in Biology and Medicine Mitochondrion. Jul, 2012 | Pubmed ID: 22750136 Is There a Link Between Mitochondrial Reserve Respiratory Capacity and Aging? Journal of Aging Research. 2012 | Pubmed ID: 22720157 Genome-wide Screens for Expressed Hypothetical Proteins Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130981 The Importance of Mitochondrial DNA in Aging and Cancer Journal of Aging Research. Mar, 2011 | Pubmed ID: 21584235 The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism Journal of Nucleic Acids. Aug, 2010 | Pubmed ID: 20862377 サイトカイン分化型ヒト初代T細胞におけるミトコンドリア呼吸のリアルタイムモニタリング Kasper Mølgaard*1, Anne Rahbech*1, Özcan Met1, Inge Marie Svane1, Per thor Straten1,3, Claus Desler2, Marlies J. W. Peeters1 1National Center for Cancer Immune Therapy, Department of Oncology, University Hospital Herlev, 2Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, 3Department of Immunology and Microbiology, Inflammation and Cancer Group, University of Copenhagen JoVE 62984 Immunology and Infection
サイトカイン分化型ヒト初代T細胞におけるミトコンドリア呼吸のリアルタイムモニタリング Kasper Mølgaard*1, Anne Rahbech*1, Özcan Met1, Inge Marie Svane1, Per thor Straten1,3, Claus Desler2, Marlies J. W. Peeters1 1National Center for Cancer Immune Therapy, Department of Oncology, University Hospital Herlev, 2Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, 3Department of Immunology and Microbiology, Inflammation and Cancer Group, University of Copenhagen JoVE 62984 Immunology and Infection